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Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: Relation to migraine activated regions

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  1. The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neurofilament light chain as biomarker in idiopathic intracranial hypertension

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  1. Vancouver Declaration II on Global Headache Patient Advocacy 2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

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BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) occurs as either a 27- or 38-amino acid neuropeptide and belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and vasoactive intestinal polypeptide have a 68% homology of their amino acid sequences and share three B-type G-protein coupled receptors: VPAC1, VPAC2 and PAC1 receptors.

METHODS/RESULTS: The distribution of PACAP-38 and its receptors in the brain is only partly described in the literature. Here, we have performed a study to provide the more general picture of this system in rat brain in order to understand a putative role in primary headaches and partly in relation to the calcitonin gene-related peptide system. We observed a rich expression of PACAP-38 and PAC1 receptor immunoreactivity in many regions throughout the cerebrum, cerebellum and brainstem. The expression pattern points to multiple functions, not least associated with pain and reactions to pain. The expression of VPAC1 and VPAC2 receptor immunoreactivity was very sparse. In several regions such as the cerebral cortex, trigeminal nucleus caudalis, hypothalamus and pons there was a close relation to calcitonin gene-related peptide expression.

CONCLUSION: The findings suggest that the rich supply of PACAP-38 and PAC1 receptors is associated with basic functional responses in the central nervous system (CNS), and there are important close anatomical relations with calcitonin gene-related peptide in CNS regions associated with migraine pathophysiology.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume40
Issue number6
Pages (from-to)527-542
Number of pages16
ISSN0333-1024
DOIs
Publication statusPublished - May 2020

    Research areas

  • CGRP, migraine-related regions, PAC, PACAP, VPAC

ID: 59203500