Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cell-specific precursor processing

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Biosynthesis of cardiac natriuretic peptides

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Posttranslational processing of progastrin

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. VIP and PACAP

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Simvastatin improves mitochondrial respiration in peripheral blood cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Circadian variations in plasma concentrations of cholecystokinin and gastrin in man

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
The singular gene for a peptide hormone is expressed not only in a specific endocrine cell type but also in other endocrine cells as well as in entirely different cells such as neurons, adipocytes, myocytes, immune cells, and cells of the sex-glands. The cellular expression pattern for each gene varies with development, time and species. Endocrine regulation is, however, based on the release of a given hormone from an endocrine cell to the general circulation from whose cappilaries the hormone reaches the specific target cell elsewhere in the body. The widespread expression of hormone genes in different cells and tissues therefore requires control of biogenesis and secretion in order to avoid interference with the function of a specific hormonal peptide from a particular endocrine cell. Several mechanisms are involved in such control, one of them being cell-specific processing of prohormones. The following pages present four examples of such cell-specific processing and the implications of the phenomenon for the use of peptide hormones as markers of diseases. Notably, sick cells - not least the neoplastic cells - often process prohormones in a manner different from that of the normal endocrine cells.
Original languageEnglish
Book seriesResults and Problems in Cell Differentiation
Volume50
Pages (from-to)45-62
Number of pages18
ISSN0080-1844
DOIs
Publication statusPublished - 1 Jan 2010

ID: 31046984