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Cell-free DNA in newly diagnosed patients with glioblastoma - a clinical prospective feasibility study

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  1. Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

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  2. Real-world evidence to guide healthcare policies in oncology

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  3. Phospho-ERK levels as predictors for chemotherapy of rectal carcinoma

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  4. Application of cell-free DNA for genomic tumor profiling: a feasibility study

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  1. Shared heritability and functional enrichment across six solid cancers

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  2. Transcriptome analysis in patients with temporal lobe epilepsy

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  3. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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  4. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

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  5. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

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Background: Glioblastoma (GB) is an incurable brain cancer with limited treatment options. The aim was to test the feasibility of using cell-free DNA (cfDNA) to support evaluation of treatment response, pseudo-progression and whether progression could be found before clinical and/or radiologic progression. Results: CfDNA fluctuated during treatment with the highest levels before diagnostic surgery and at progression. An increase was seen in 3 out of 4 patients at the time of progression while no increase was seen in 3 out of 4 patients without progression. CfDNA levels could aid in 3 out of 3 questionable cases of pseudo-progression. Methods: Eight newly diagnosed GB patients were included. Blood samples were collected prior to diagnosis, before start and during oncologic treatment until progression. Seven patients received concurrent radiotherapy/Temozolomide with adjuvant Temozolomide with one of the patients included in a clinical trial with either immunotherapy or placebo as add-on. One patient received radiation alone. CfDNA concentration was determined for each blood sample. Conclusions: It was feasible to measure cfDNA concentration. Despite the limited cohort size, there was a good tendency between cfDNA and treatment course and -response, respectively with the highest levels at progression.

Original languageEnglish
JournalOncotarget
Volume10
Issue number43
Pages (from-to)4397-4406
Number of pages10
ISSN1949-2553
DOIs
Publication statusPublished - 8 Jul 2019

ID: 58390158