Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019

Anne Line Engsbro; Hans Søe Riis Jespersen; Maria Ingeborg Goldschmidt; Sarah Mollerup; Peder Worning; Martin Schou Pedersen; Henrik Westh; Uffe Vest Schneider

doi:10.2807/1560-7917.ES.2019.24.21.1900289

Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019

Anne Line Engsbro
, Hans Søe Riis Jespersen
, Maria Ingeborg Goldschmidt
, Sarah Mollerup
, Peder Worning
, Martin Schou Pedersen
, Henrik Westh
, Uffe Vest Schneider

30 Citations (Scopus)

Abstract

We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases.

Original language	English
Journal	Eurosurveillance
Volume	24
Issue number	21
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2019.24.21.1900289
Publication status	Published - 23 May 2019

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10.2807/1560-7917.ES.2019.24.21.1900289

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title = "Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019",

abstract = "We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases.",

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AU - Engsbro, Anne Line

AU - Riis Jespersen, Hans Søe

AU - Goldschmidt, Maria Ingeborg

AU - Mollerup, Sarah

AU - Worning, Peder

AU - Pedersen, Martin Schou

AU - Westh, Henrik

AU - Schneider, Uffe Vest

PY - 2019/5/23

Y1 - 2019/5/23

N2 - We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases.

AB - We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases.

UR - https://www.scopus.com/pages/publications/85067304994

U2 - 10.2807/1560-7917.ES.2019.24.21.1900289

DO - 10.2807/1560-7917.ES.2019.24.21.1900289

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SN - 1560-7917

VL - 24

JO - Eurosurveillance

JF - Eurosurveillance

IS - 21

ER -

Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019

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