Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

CDHR3 Genetics and Rhinovirus C Respiratory Illnesses

Research output: Contribution to journalJournal articleResearchpeer-review

  1. High Prevalence of Laryngeal Obstruction during Exercise in Severe Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exposure Interaction - A Life-long Phenomenon with Relevance to Chronic Obstructive Pulmonary Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. How Do Dual Long-acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Fletcher and Peto 40 Years on. A tribute and reflection

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Laryngeal Dysfunction - Assessment and Management for the Clinician

    Research output: Contribution to journalReviewResearchpeer-review

  1. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Protocol for Extraction of Infective Viromes Suitable for Metagenomics Sequencing from Low Volume Fecal Samples

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sensitivity of Multiple Breath Washout to Detect Mild to Moderate Asthma in Adolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background Experimental evidence suggests that CDHR3 is a receptor for rhinovirus-C (RV-C), and a missense variant in this gene (rs6967330) is associated with childhood asthma with severe exacerbations. Objective To determine whether rs6967330 influences RV-C infections and illnesses in early childhood. Methods We studied associations between rs6967330 and respiratory infections and illnesses in the COPSAC2010 and COAST birth cohorts, where respiratory infections were monitored prospectively for the first 3 years of life. Nasal samples were collected during acute infections in both cohorts and during asymptomatic periods in COAST and analyzed for RV-A, RV-B and RV-C, and other common respiratory viruses. Results The CDHR3 asthma risk-allele (rs6967330-A) was associated with increased risk of respiratory tract illnesses (IRR 1.14 [1.05-1.23], P=0.003). Particularly, this variant was associated with risk of respiratory episodes with detection of RV-C in COPSAC2010 (IRR 1.89 [1.14-3.05], P=0.01) and in COAST (IRR 1.37 [1.02-1.82], P=0.03) children, and in a combined meta-analysis (IRR 1.51 [1.13-2.02], P=0.006). In contrast, the variant was not associated with illnesses related to other viruses (IRR 1.07 [0.92-1.25], P=0.37). Consistent with these observations, the CDHR3 variant was associated with increased detection of RV-C but not of other viruses during scheduled visits at specific ages. Conclusion The CDHR3 asthma risk allele is associated specifically with RV-C illnesses in two birth cohorts. This clinical evidence supports earlier molecular evidence indicating that CDHR3 functions as an RV-C receptor, and raises the possibility of preventing RV-C infections by targeting CDHR3.

Original languageEnglish
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume197
Issue number5
Pages (from-to)589-594
Number of pages6
ISSN1073-449X
DOIs
Publication statusPublished - 1 Mar 2018

    Research areas

  • Journal Article

ID: 52651086