CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis

Sophine B Krintel; Laurent Essioux; Assaf Wool; Julia S Johansen; Ehud Schreiber; Tomer Zekharya; Pinchas Akiva; Mikkel Østergaard; Merete L Hetland

doi:10.1371/journal.pone.0038539

CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis

Sophine B Krintel, Laurent Essioux, Assaf Wool, Julia S Johansen, Ehud Schreiber, Tomer Zekharya, Pinchas Akiva, Mikkel Østergaard, Merete L Hetland

Oncology

18 Citations (Scopus)

Abstract

TNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in patients with rheumatoid arthritis (RA).

Original language	English
Publication date	2012
DOIs	https://doi.org/10.1371/journal.pone.0038539
Publication status	Published - 2012

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title = "CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis",

abstract = "TNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in patients with rheumatoid arthritis (RA).",

author = "Krintel, {Sophine B} and Laurent Essioux and Assaf Wool and Johansen, {Julia S} and Ehud Schreiber and Tomer Zekharya and Pinchas Akiva and Mikkel {\O}stergaard and Hetland, {Merete L}",

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AU - Krintel, Sophine B

AU - Essioux, Laurent

AU - Wool, Assaf

AU - Johansen, Julia S

AU - Schreiber, Ehud

AU - Zekharya, Tomer

AU - Akiva, Pinchas

AU - Østergaard, Mikkel

AU - Hetland, Merete L

PY - 2012

Y1 - 2012

N2 - TNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in patients with rheumatoid arthritis (RA).

AB - TNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in patients with rheumatoid arthritis (RA).

U2 - 10.1371/journal.pone.0038539

DO - 10.1371/journal.pone.0038539

M3 - Net publication - Internet publication

C2 - 22685579

ER -

CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis

Abstract

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