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CD4(+) memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosis

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  1. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

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  2. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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  3. Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

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  4. Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis

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  1. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  2. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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  3. Functional neuroimaging of recovery from motor conversion disorder: A case report

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  4. Structural and cognitive correlates of fatigue in progressive multiple sclerosis

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An aberrant immune activation is believed to be important in the pathogenesis of multiple sclerosis (MS). Expression of CD4(+) T lymphocyte surface molecules indicative of immune activation and effector functions has been correlated with disease severity and activity. CD4(+) CD45R0(+) CD26(high) memory T lymphocytes contained the high levels of markers of Th1, activation, and effector functions and cell counts of this subset correlated with MS disease severity. This subset had lower expression of PD-1, CCR4, and L-selectin in MS than in controls. These changes were only partially normalised by treatment with interferon-beta. We point to this subset as a putative target for immunological monitoring of MS disease activity and of treatment efficacy.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume181
Issue number1-2
Pages (from-to)157-64
Number of pages8
ISSN0165-5728
DOIs
Publication statusPublished - Dec 2006

    Research areas

  • Adult, Antigens, CD45, Biological Markers, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Dipeptidyl Peptidase 4, Drug Monitoring, Female, Flow Cytometry, Humans, Immunologic Factors, Immunologic Memory, Immunophenotyping, Interferon-beta, Lymphocyte Activation, Male, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Th1 Cells

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