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CD4(+) memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. MAIT cell subtypes in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. MAIT cell subtypes in multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Amyloid transthyretinkardiomyopati

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Intoxicationer og ernæringsdeficit

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

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An aberrant immune activation is believed to be important in the pathogenesis of multiple sclerosis (MS). Expression of CD4(+) T lymphocyte surface molecules indicative of immune activation and effector functions has been correlated with disease severity and activity. CD4(+) CD45R0(+) CD26(high) memory T lymphocytes contained the high levels of markers of Th1, activation, and effector functions and cell counts of this subset correlated with MS disease severity. This subset had lower expression of PD-1, CCR4, and L-selectin in MS than in controls. These changes were only partially normalised by treatment with interferon-beta. We point to this subset as a putative target for immunological monitoring of MS disease activity and of treatment efficacy.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume181
Issue number1-2
Pages (from-to)157-64
Number of pages8
ISSN0165-5728
DOIs
Publication statusPublished - Dec 2006

    Research areas

  • Adult, Antigens, CD45, Biological Markers, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Dipeptidyl Peptidase 4, Drug Monitoring, Female, Flow Cytometry, Humans, Immunologic Factors, Immunologic Memory, Immunophenotyping, Interferon-beta, Lymphocyte Activation, Male, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Th1 Cells

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