CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

Julie Christine Gaardbo, Hans Jakob Hartling, Kristina Thorsteinsson, Henrik Ullum, Susanne Dam Nielsen

20 Citations (Scopus)

Abstract

CD8+ Tc17 cells with pro-inflammatory properties have only recently been acknowledged, and Tc17 cells in HIV-infection are undescribed. CD3+CD8+CD161 Tc17 cells and the production of Interleukin-17 were examined in untreated and treated HIV-infected patients, HIV-HCV co-infected patients and healthy controls. Depletion of CD3+CD8+CD161 Tc17 cells and diminished production of Interleukin-17 in HIV-infected patients was found. The level of Tc17 cells was associated with the level of the CD4+ count in treated patients.
Original languageEnglish
JournalAIDS
Volume27
Issue number4
Pages (from-to)659-62
ISSN0269-9370
DOIs
Publication statusPublished - 2012

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