Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Causes and Risk Factors of Pediatric Spontaneous Intracranial Hemorrhage-A Systematic Review

Research output: Contribution to journalReviewpeer-review

  1. Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications

    Research output: Contribution to journalJournal articlepeer-review

  2. A deep learning-based whole-body solution for PET/MRI attenuation correction

    Research output: Contribution to journalJournal articlepeer-review

  3. An fMRI-compatible system for targeted electrical stimulation

    Research output: Contribution to journalJournal articlepeer-review

View graph of relations

Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous intracranial hemorrhages is lacking. The aim of this study is to systematically analyze the published data on the etiologies and risk factors of pediatric spontaneous intracranial hemorrhage. This systematic review was performed in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A search in PubMed, Embase, Scopus, Web of Science and Cochrane Library was conducted aiming for articles published in year 2000 and later, containing data on etiology and risk factors of spontaneous intracranial hemorrhages in unselected cohorts of patients aged between 1 month and 18 years. As a result, forty studies were eligible for data extraction and final analysis. These included 7931 children and adolescents with 4009 reported etiologies and risk factors. A marked variety of reported etiologies and risk factors among studies was observed. Vascular etiologies were the most frequently reported cause of pediatric spontaneous intracranial hemorrhages (n = 1727, 43.08% of all identified etiologies or risk factors), with AVMs being the most common vascular cause (n = 1226, 70.99% of all vascular causes). Hematological and systemic causes, brain tumors, intracranial infections and cardiac causes were less commonly encountered risk factors and etiologies.

Original languageEnglish
Article number1459
JournalDiagnostics
Volume12
Issue number6
ISSN2075-4418
DOIs
Publication statusPublished - 13 Jun 2022

ID: 79083341