CASP8 D302H and meningioma risk: an analysis of five case-control series

Lara Bethke; Kate Sullivan; Emily Webb; Anne Murray; Minouk Schoemaker; Anssi Auvinen; Anne Kiuru; Tiina Salminen; Christoffer Johansen; Helle Collatz Christensen; Kenneth Muir; Patricia McKinney; Sarah Hepworth; Polyxeni Dimitropoulou; Artitaya Lophatananon; Maria Feychting; Stefan Lönn; Anders Ahlbom; Beatrice Malmer; Roger Henriksson; Anthony Swerdlow; Richard Houlston

doi:10.1016/j.canlet.2008.08.010

CASP8 D302H and meningioma risk: an analysis of five case-control series

Lara Bethke, Kate Sullivan, Emily Webb, Anne Murray, Minouk Schoemaker, Anssi Auvinen, Anne Kiuru, Tiina Salminen, Christoffer Johansen, Helle Collatz Christensen, Kenneth Muir, Patricia McKinney, Sarah Hepworth, Polyxeni Dimitropoulou, Artitaya Lophatananon, Maria Feychting, Stefan Lönn, Anders Ahlbom, Beatrice Malmer, Roger HenrikssonAnthony Swerdlow, Richard Houlston

19 Citations (Scopus)

Abstract

Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.

Original language	English
Journal	Cancer Letters
Volume	273
Issue number	2
Pages (from-to)	312-5
Number of pages	4
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2008.08.010
Publication status	Published - 18 Jan 2009
Externally published	Yes

Keywords

Adult
Aged
Alleles
Apoptosis
Case-Control Studies
Caspase 8/genetics
Female
Genetic Variation
Humans
Male
Meningeal Neoplasms/genetics
Meningioma/diagnosis
Middle Aged
Polymorphism, Genetic
Risk

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10.1016/j.canlet.2008.08.010

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Bethke, L., Sullivan, K., Webb, E., Murray, A., Schoemaker, M., Auvinen, A., Kiuru, A., Salminen, T., Johansen, C., Christensen, H. C., Muir, K., McKinney, P., Hepworth, S., Dimitropoulou, P., Lophatananon, A., Feychting, M., Lönn, S., Ahlbom, A., Malmer, B., ... Houlston, R. (2009). CASP8 D302H and meningioma risk: an analysis of five case-control series. Cancer Letters, 273(2), 312-5. https://doi.org/10.1016/j.canlet.2008.08.010

Bethke, L, Sullivan, K, Webb, E, Murray, A, Schoemaker, M, Auvinen, A, Kiuru, A, Salminen, T, Johansen, C, Christensen, HC, Muir, K, McKinney, P, Hepworth, S, Dimitropoulou, P, Lophatananon, A, Feychting, M, Lönn, S, Ahlbom, A, Malmer, B, Henriksson, R, Swerdlow, A & Houlston, R 2009, 'CASP8 D302H and meningioma risk: an analysis of five case-control series', Cancer Letters, vol. 273, no. 2, pp. 312-5. https://doi.org/10.1016/j.canlet.2008.08.010

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title = "CASP8 D302H and meningioma risk: an analysis of five case-control series",

abstract = "Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95\% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.",

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author = "Lara Bethke and Kate Sullivan and Emily Webb and Anne Murray and Minouk Schoemaker and Anssi Auvinen and Anne Kiuru and Tiina Salminen and Christoffer Johansen and Christensen, \{Helle Collatz\} and Kenneth Muir and Patricia McKinney and Sarah Hepworth and Polyxeni Dimitropoulou and Artitaya Lophatananon and Maria Feychting and Stefan L{\"o}nn and Anders Ahlbom and Beatrice Malmer and Roger Henriksson and Anthony Swerdlow and Richard Houlston",

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doi = "10.1016/j.canlet.2008.08.010",

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T2 - an analysis of five case-control series

AU - Bethke, Lara

AU - Sullivan, Kate

AU - Webb, Emily

AU - Murray, Anne

AU - Schoemaker, Minouk

AU - Auvinen, Anssi

AU - Kiuru, Anne

AU - Salminen, Tiina

AU - Johansen, Christoffer

AU - Christensen, Helle Collatz

AU - Muir, Kenneth

AU - McKinney, Patricia

AU - Hepworth, Sarah

AU - Dimitropoulou, Polyxeni

AU - Lophatananon, Artitaya

AU - Feychting, Maria

AU - Lönn, Stefan

AU - Ahlbom, Anders

AU - Malmer, Beatrice

AU - Henriksson, Roger

AU - Swerdlow, Anthony

AU - Houlston, Richard

PY - 2009/1/18

Y1 - 2009/1/18

N2 - Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.

AB - Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.

KW - Adult

KW - Aged

KW - Alleles

KW - Apoptosis

KW - Case-Control Studies

KW - Caspase 8/genetics

KW - Female

KW - Genetic Variation

KW - Humans

KW - Male

KW - Meningeal Neoplasms/genetics

KW - Meningioma/diagnosis

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Risk

UR - https://www.scopus.com/pages/publications/57349105754

U2 - 10.1016/j.canlet.2008.08.010

DO - 10.1016/j.canlet.2008.08.010

M3 - Journal article

C2 - 18823701

SN - 0304-3835

VL - 273

SP - 312

EP - 315

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

CASP8 D302H and meningioma risk: an analysis of five case-control series

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Keywords

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