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Carotid-femoral pulse wave velocity is a risk marker for complications in persons with type 1 diabetes

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@conference{4bd1a5e5a27b450496a40f5905274e77,
title = "Carotid-femoral pulse wave velocity is a risk marker for complications in persons with type 1 diabetes",
abstract = "BackgroundThe value of carotid-femoral pulse wave velocity (cfPWV) as a risk factor for complications remains to be determined in type 1 diabetes (T1D). We investigated the ability of cfPWV to predict all-cause mortality, cardiovascular events (CVE) and renal outcomes in persons with T1D. MethodsCfPWV was measured using the SphygmoCor device in 633 persons with T1D. Median (interquartile range) follow-up was 6.2 (5.8−6.7) years and endpoints were traced through national registers and electronic medical records and included mortality, composite CVE, decline in eGFR ≥30{\%}, progression in albuminuria group and ESRD. Hazard ratios (HR) were calculated per 1 standard derivation (SD) increase. Yearly change in eGFR and albuminuria were calculated for a median of 5.5 years. Adjustments included age, sex, HbA1c, mean arterial pressure, BMI, LDL-cholesterol, smoking, urine albumin excretion rate and eGFR.ResultsThe cohort included 45{\%} women, mean ± SD age was 54 ± 13 years and cfPWV 10.4 ± 3.3 m/s. After adjustment, higher cfPWV was associated with increased risk of mortality (n=48; HR:1.36; 95{\%}CI 1.004−1.85); composite CVE (n=81; HR:1.31; 1.01−1.70); decline in eGFR ≥ 30{\%} (n=90;HR: 1.38; 1.06−1.79) and progression in albuminuria (n=34; HR:1.59; 1.10−2.32), but not with ESRD (n=19; HR: 1.18; 0.62−2.26). Higher cfPWV was associated with a steeper decline in eGFR and a steeper increase in albuminuria after adjustment (p=0.013 and 0.002, respectively). ConclusionsIn this T1D cohort, cfPWV was consistently and independently associated with a higher risk of mortality, CVE, decline in renal function and progression in albuminuria. Measurement of cfPWV may have a promising role in risk stratification in T1D.",
author = "Tougaard, {Ninna Hahn} and Simone Theilade and Winther, {Signe Abitz} and Nete Tofte and Ahluwalia, {Tarunveer Singh} and Hansen, {Tine Willum} and Peter Rossing and Marie Frimodt-M{\o}ller",
year = "2020",
month = "1",
day = "18",
language = "English",
note = "null ; Conference date: 17-01-2020 Through 18-01-2020",

}

RIS

TY - ABST

T1 - Carotid-femoral pulse wave velocity is a risk marker for complications in persons with type 1 diabetes

AU - Tougaard, Ninna Hahn

AU - Theilade, Simone

AU - Winther, Signe Abitz

AU - Tofte, Nete

AU - Ahluwalia, Tarunveer Singh

AU - Hansen, Tine Willum

AU - Rossing, Peter

AU - Frimodt-Møller, Marie

PY - 2020/1/18

Y1 - 2020/1/18

N2 - BackgroundThe value of carotid-femoral pulse wave velocity (cfPWV) as a risk factor for complications remains to be determined in type 1 diabetes (T1D). We investigated the ability of cfPWV to predict all-cause mortality, cardiovascular events (CVE) and renal outcomes in persons with T1D. MethodsCfPWV was measured using the SphygmoCor device in 633 persons with T1D. Median (interquartile range) follow-up was 6.2 (5.8−6.7) years and endpoints were traced through national registers and electronic medical records and included mortality, composite CVE, decline in eGFR ≥30%, progression in albuminuria group and ESRD. Hazard ratios (HR) were calculated per 1 standard derivation (SD) increase. Yearly change in eGFR and albuminuria were calculated for a median of 5.5 years. Adjustments included age, sex, HbA1c, mean arterial pressure, BMI, LDL-cholesterol, smoking, urine albumin excretion rate and eGFR.ResultsThe cohort included 45% women, mean ± SD age was 54 ± 13 years and cfPWV 10.4 ± 3.3 m/s. After adjustment, higher cfPWV was associated with increased risk of mortality (n=48; HR:1.36; 95%CI 1.004−1.85); composite CVE (n=81; HR:1.31; 1.01−1.70); decline in eGFR ≥ 30% (n=90;HR: 1.38; 1.06−1.79) and progression in albuminuria (n=34; HR:1.59; 1.10−2.32), but not with ESRD (n=19; HR: 1.18; 0.62−2.26). Higher cfPWV was associated with a steeper decline in eGFR and a steeper increase in albuminuria after adjustment (p=0.013 and 0.002, respectively). ConclusionsIn this T1D cohort, cfPWV was consistently and independently associated with a higher risk of mortality, CVE, decline in renal function and progression in albuminuria. Measurement of cfPWV may have a promising role in risk stratification in T1D.

AB - BackgroundThe value of carotid-femoral pulse wave velocity (cfPWV) as a risk factor for complications remains to be determined in type 1 diabetes (T1D). We investigated the ability of cfPWV to predict all-cause mortality, cardiovascular events (CVE) and renal outcomes in persons with T1D. MethodsCfPWV was measured using the SphygmoCor device in 633 persons with T1D. Median (interquartile range) follow-up was 6.2 (5.8−6.7) years and endpoints were traced through national registers and electronic medical records and included mortality, composite CVE, decline in eGFR ≥30%, progression in albuminuria group and ESRD. Hazard ratios (HR) were calculated per 1 standard derivation (SD) increase. Yearly change in eGFR and albuminuria were calculated for a median of 5.5 years. Adjustments included age, sex, HbA1c, mean arterial pressure, BMI, LDL-cholesterol, smoking, urine albumin excretion rate and eGFR.ResultsThe cohort included 45% women, mean ± SD age was 54 ± 13 years and cfPWV 10.4 ± 3.3 m/s. After adjustment, higher cfPWV was associated with increased risk of mortality (n=48; HR:1.36; 95%CI 1.004−1.85); composite CVE (n=81; HR:1.31; 1.01−1.70); decline in eGFR ≥ 30% (n=90;HR: 1.38; 1.06−1.79) and progression in albuminuria (n=34; HR:1.59; 1.10−2.32), but not with ESRD (n=19; HR: 1.18; 0.62−2.26). Higher cfPWV was associated with a steeper decline in eGFR and a steeper increase in albuminuria after adjustment (p=0.013 and 0.002, respectively). ConclusionsIn this T1D cohort, cfPWV was consistently and independently associated with a higher risk of mortality, CVE, decline in renal function and progression in albuminuria. Measurement of cfPWV may have a promising role in risk stratification in T1D.

M3 - Conference abstract for conference

ER -

ID: 59055846