Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes

Sara H Naaman*, Hatice I Mizrak, Nanna Lind, Jens C Laursen, Huda Kufaishi, Marie M B Christensen, Ajenthen G Ranjan, Kirsten Nørgaard, Christian S Hansen

*Corresponding author for this work

Abstract

OBJECTIVE: We investigated the association between the cardiovascular autonomic neuropathy (CAN) diagnosis and glucose variability (GV) in type 1 diabetes (T1D), as autonomic dysfunction previously has been associated with increased GV.

RESEARCH DESIGN AND METHODS: CAN was assessed by three recommended cardiovascular reflex tests (CARTs). Glucose metrics were obtained from 10-day blinded continuous glucose monitoring (CGM). Between-group differences in GV indices were assessed by regression analyses in 24 participants with T1D with CAN and 24 matched control subjects without CAN.

RESULTS: The CAN diagnosis was associated with 4.9% (95% CI 1.0, 8.7) higher coefficient of variation (CV) (P = 0.014), 0.7 mmol/L (0.3, 1.1) higher SD (P = 0.002) of glucose, and 1.4 mmol/mol (0.0, 2.7) higher mean amplitude of glycemic excursions (P = 0.047). Lower measures of CARTs were associated with higher CV, SD, and time above range values.

CONCLUSIONS: The CAN diagnosis associates with a significantly higher GV in T1D, despite a high prevalence of routine CGM use.

Original languageEnglish
JournalDiabetes Care
Volume45
Issue number10
Pages (from-to)2461-2465
Number of pages5
ISSN1935-5548
DOIs
Publication statusPublished - 23 Aug 2022

Keywords

  • Autonomic Nervous System
  • Blood Glucose
  • Blood Glucose Self-Monitoring
  • Cardiovascular System
  • Diabetes Mellitus, Type 1/complications
  • Glycated Hemoglobin A
  • Humans

Fingerprint

Dive into the research topics of 'Cardiovascular Autonomic Neuropathy Is Associated With Increased Glucose Variability in People With Type 1 Diabetes'. Together they form a unique fingerprint.

Cite this