Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cardiac vagal tone as a novel screening tool to recognize asymptomatic cardiovascular autonomic neuropathy: Aspects of utility in type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk of diabetes among related and unrelated family members

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exercise training is associated with reduced pains from the musculoskeletal system in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Anne-Marie Wegeberg
  • Elin D Lunde
  • Sam Riahi
  • Niels Ejskjaer
  • Asbjørn M Drewes
  • Birgitte Brock
  • Rodica Pop-Busui
  • Christina Brock
View graph of relations

Aims: To test the performance of the cardiac vagal tone (CVT) derived from a 5-minute ECG recording compared with the standardized cardiovascular autonomic reflex tests (CARTs). Methods: Cross-sectional study included 56 well-phenotyped adults with type 1 diabetes (19–71 years, 2–54 years disease-duration). Autonomic testing included: standardized CARTs obtained with the VAGUS™, CVT, and indices of heart rate variability (HRV) obtained at 24- and 120-hour, and electrochemical skin conductance assessed with SUDOSCAN®. ROC AUC and cut-off values were calculated for CVT to recognize CAN based on ≥ 2 (established CAN, n = 7) or 1 (borderline CAN, n = 9) abnormal CARTs and compared to HRV indices and electrochemical skin conductance. Results: Established CAN: The cut-off CVT value of 3.2LVS showed 67% sensitivity and 87% specificity (p = 0.01). Indices of HRV at either 24-hour (AUC > 0.90) and 120-hour (AUC > 0.88) performed better than CVT. Borderline CAN: The cut-off CVT value of 5.2LVS indicated 88% sensitivity and 63% specificity (p = 0.07). CVT performed better than HRV indices (AUC < 0.72). Electrochemical skin conductance (AUC:0.63–0.72) had lower sensitivity and specificity compared with CVT. Conclusions: Implementation of CVT with a clinically applicable cut-off value may be considered a quicker and accessible screening tool which could ultimately decrease the number of unrecognized CAN and initiate earlier prevention initiatives.

Original languageEnglish
Article number108517
JournalDiabetes Research and Clinical Practice
Volume170
Pages (from-to)108517
ISSN0168-8227
DOIs
Publication statusPublished - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Cardiac vagal tone, Cardiovascular autonomic neuropathy, Diabetes Mellitus, Type 1, Diabetic neuropathies, Screening, Sensitivity and specificity

ID: 61262311