Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cardiac sympathetic imaging with mIBG in cirrhosis and portal hypertension: Relation to autonomic and cardiac function

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cardiac dysfunction in cirrhosis: a 2-yr longitudinal follow-up study using advanced cardiac imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effect of insulin on natriuretic peptide gene expression in porcine heart

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Autonomic and cardiac dysfunction is frequent in cirrhosis, and includes increased sympathetic nervous activity, impaired heart rate variability (HRV) and baroreflex sensitivity (BRS). Quantified (123)I-metaiodobenzylguanidine (mIBG) scintigraphy reflects cardiac noradrenaline uptake and in patients with cardiac failure it predicts outcome. In this study we aimed to investigate cardiac sympathetic function in cirrhosis by mIBG scintigraphy in relation to cardiovascular function. Ten patients with cirrhosis and 10 matched healthy controls participated in the study. Heart/mediastinum (H/M) ratios of mIBG uptake were calculated 15 and 230 minutes after intravenous injection of mIBG. Furthermore, washout rate (WOR) of mIBG was calculated. The patients underwent a liver vein catherization with determination of splanchnic and systemic haemodynamics and measurement of HRV and BRS. mIBG-scintigraphy revealed significantly increased WOR in patients with cirrhosis compared to controls (p
Original languageEnglish
JournalAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Volume308
Issue number11
Pages (from-to)GL228-GL235
Number of pages8
ISSN0193-1857
DOIs
Publication statusPublished - 2012

ID: 36418900