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Cardiac sympathetic imaging with mIBG in cirrhosis and portal hypertension: Relation to autonomic and cardiac function

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  1. Cardiac dysfunction in cirrhosis: a 2-yr longitudinal follow-up study using advanced cardiac imaging

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  2. Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

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  1. Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon

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  2. Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction

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  3. Transcriptome analysis in patients with temporal lobe epilepsy

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  4. Increased abundance of proteobacteria in aggressive Crohn's disease seven years after diagnosis

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Autonomic and cardiac dysfunction is frequent in cirrhosis, and includes increased sympathetic nervous activity, impaired heart rate variability (HRV) and baroreflex sensitivity (BRS). Quantified (123)I-metaiodobenzylguanidine (mIBG) scintigraphy reflects cardiac noradrenaline uptake and in patients with cardiac failure it predicts outcome. In this study we aimed to investigate cardiac sympathetic function in cirrhosis by mIBG scintigraphy in relation to cardiovascular function. Ten patients with cirrhosis and 10 matched healthy controls participated in the study. Heart/mediastinum (H/M) ratios of mIBG uptake were calculated 15 and 230 minutes after intravenous injection of mIBG. Furthermore, washout rate (WOR) of mIBG was calculated. The patients underwent a liver vein catherization with determination of splanchnic and systemic haemodynamics and measurement of HRV and BRS. mIBG-scintigraphy revealed significantly increased WOR in patients with cirrhosis compared to controls (p
Original languageEnglish
JournalAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Volume308
Issue number11
Pages (from-to)GL228-GL235
Number of pages8
ISSN0193-1857
DOIs
Publication statusPublished - 2012

ID: 36418900