Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity

Rikke Due-Andersen; Thomas Høi-Hansen; Niels Vidiendal Olsen; Charlotte Ellen Larroude; Jørgen Kim Kanters; Frans Boomsma; Ulrik Pedersen-Bjergaard; Birger Thorsteinsson

doi:10.1093/europace/eum286

Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity

Rikke Due-Andersen, Thomas Høi-Hansen, Niels Vidiendal Olsen, Charlotte Ellen Larroude, Jørgen Kim Kanters, Frans Boomsma, Ulrik Pedersen-Bjergaard, Birger Thorsteinsson

4 Citations (Scopus)

Abstract

AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans.

METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables.

CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.

Original language	English
Journal	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Volume	10
Issue number	2
Pages (from-to)	219-26
Number of pages	8
ISSN	1099-5129
DOIs	https://doi.org/10.1093/europace/eum286
Publication status	Published - Feb 2008

Keywords

Adult
Cross-Over Studies
Electrocardiography, Ambulatory
Humans
Hypoglycemia
Hypoxia
Insulin
Insulin, Regular, Pork
Long QT Syndrome
Male
Oxygen Inhalation Therapy
Renin-Angiotensin System
Risk Factors
Single-Blind Method
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Access to Document

10.1093/europace/eum286

Cite this

Due-Andersen, R., Høi-Hansen, T., Olsen, N. V., Larroude, C. E., Kanters, J. K., Boomsma, F., Pedersen-Bjergaard, U., & Thorsteinsson, B. (2008). Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 10(2), 219-26. https://doi.org/10.1093/europace/eum286

Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. / Due-Andersen, Rikke; Høi-Hansen, Thomas; Olsen, Niels Vidiendal et al.
In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 10, No. 2, 02.2008, p. 219-26.

Research output: Contribution to journal › Journal article › Research › peer-review

Due-Andersen, R, Høi-Hansen, T, Olsen, NV, Larroude, CE, Kanters, JK, Boomsma, F, Pedersen-Bjergaard, U & Thorsteinsson, B 2008, 'Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity', Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 10, no. 2, pp. 219-26. https://doi.org/10.1093/europace/eum286

Due-Andersen R, Høi-Hansen T, Olsen NV, Larroude CE, Kanters JK, Boomsma F et al. Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2008 Feb;10(2):219-26. doi: 10.1093/europace/eum286

Due-Andersen, Rikke ; Høi-Hansen, Thomas ; Olsen, Niels Vidiendal et al. / Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males : impact of renin-angiotensin system activity. In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2008 ; Vol. 10, No. 2. pp. 219-26.

@article{00267639795e412680cc33f33ae488a1,

title = "Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity",

abstract = "AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans.METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables.CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.",

keywords = "Adult, Cross-Over Studies, Electrocardiography, Ambulatory, Humans, Hypoglycemia, Hypoxia, Insulin, Insulin, Regular, Pork, Long QT Syndrome, Male, Oxygen Inhalation Therapy, Renin-Angiotensin System, Risk Factors, Single-Blind Method, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",

author = "Rikke Due-Andersen and Thomas H{\o}i-Hansen and Olsen, \{Niels Vidiendal\} and Larroude, \{Charlotte Ellen\} and Kanters, \{J{\o}rgen Kim\} and Frans Boomsma and Ulrik Pedersen-Bjergaard and Birger Thorsteinsson",

year = "2008",

month = feb,

doi = "10.1093/europace/eum286",

language = "English",

volume = "10",

pages = "219--26",

journal = "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males

T2 - impact of renin-angiotensin system activity

AU - Due-Andersen, Rikke

AU - Høi-Hansen, Thomas

AU - Olsen, Niels Vidiendal

AU - Larroude, Charlotte Ellen

AU - Kanters, Jørgen Kim

AU - Boomsma, Frans

AU - Pedersen-Bjergaard, Ulrik

AU - Thorsteinsson, Birger

PY - 2008/2

Y1 - 2008/2

N2 - AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans.METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables.CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.

AB - AIMS: Activity in the renin-angiotensin system (RAS) may influence the susceptibility to cardiac arrhythmia. To study the effect of basal RAS activity on cardiac repolarization during myocardial stress induced by hypoglycaemia or hypoxaemia in healthy humans.METHODS AND RESULTS: Ten subjects with high RAS activity and 10 subjects with low RAS activity were studied on three different occasions: (i) hypoglycaemia (nadir P-glucose 2.7 +/- 0.5 mmol/L), (ii) hypoxaemia (nadir pO(2) 5.8 +/- 0.5 kPa), and (iii) normoglycaemic normoxia (control day). QT parameters were registered by Holter monitoring. Hypoglycaemia and hypoxaemia induced QTc prolongation (P < 0.001, both stimuli). The QT/RR slope and the VR increased as a function of hypoglycaemia, but were unaffected by hypoxaemia. Low RAS activity was associated with a steeper QT/RR slope in the recovery phase after both stimuli: hypoglycaemia: P = 0.04; hypoxia: P = 0.03. RAS activity had no impact on QTc [P = 0.48 (hypoglycaemia) and P = 0.40 (hypoxaemia)] or any of the other outcome variables.CONCLUSION: Basal RAS activity has significant impact on QT dynamics, but not the corrected QT interval, during recovery from hypoglycaemia and hypoxaemia. The impact, however, is modest and more subtle than initially expected. The clinical relevance is unclear.

KW - Adult

KW - Cross-Over Studies

KW - Electrocardiography, Ambulatory

KW - Humans

KW - Hypoglycemia

KW - Hypoxia

KW - Insulin

KW - Insulin, Regular, Pork

KW - Long QT Syndrome

KW - Male

KW - Oxygen Inhalation Therapy

KW - Renin-Angiotensin System

KW - Risk Factors

KW - Single-Blind Method

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

UR - https://www.scopus.com/pages/publications/41949122896

U2 - 10.1093/europace/eum286

DO - 10.1093/europace/eum286

M3 - Journal article

C2 - 18204042

SN - 1099-5129

VL - 10

SP - 219

EP - 226

JO - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

IS - 2

ER -

Cardiac repolarization during hypoglycaemia and hypoxaemia in healthy males: impact of renin-angiotensin system activity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this