Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging

U K Radunski; O Franzen; A Barmeyer; M Lange; G Lund; V Rudolph; M Schlüter; G Adam; H Reichenspurner; S Blankenberg; S Baldus; K Muellerleile

doi:10.1055/s-0034-1366216

Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging

U K Radunski, O Franzen, A Barmeyer, M Lange, G Lund, V Rudolph, M Schlüter, G Adam, H Reichenspurner, S Blankenberg, S Baldus, K Muellerleile

8 Citations (Scopus)

Abstract

PURPOSE: Percutaneous mitral valve repair with the MitraClip device (Abbott Vascular, Redwood City, California, USA) is a novel therapeutic option in patients with mitral regurgitation. This study evaluated the feasibility of cardiac volume measurements by cardiovascular magnetic resonance imaging (CMR) to assess reverse myocardial remodeling in patients after MitraClip implantation.

MATERIALS AND METHODS: 12 patients underwent CMR at baseline (BL) before and at 6 months follow-up (FU) after MitraClip implantation. Cine-CMR was performed in short- and long-axes for the assessment of left ventricular (LV), right ventricular (RV) and left atrial (LA) volumes.

RESULTS: Assessment of endocardial contours was not compromised by the device-related artifact. No significant differences in observer variances were observed for LV, RV and LA volume measurements between BL and FU. LV end-diastolic (median 127 [IQR 96 - 150] vs. 112 [86 - 150] ml/m(2); p = 0.03) and LV end-systolic (82 [54 - 91] vs. 69 [48 - 99] ml/m(2); p = 0.03) volume indices decreased significantly from BL to FU. No significant differences were found for RV end-diastolic (94 [75 - 103] vs. 99 [77 - 123] ml/m(2); p = 0.91), RV end-systolic (48 [42 - 80] vs. 51 [40 - 81] ml/m(2); p = 0.48), and LA (87 [55 - 124] vs. 92 [48 - 137] ml/m(2); p = 0.20) volume indices between BL and FU.

CONCLUSION: CMR enables the assessment of cardiac volumes in patients after MitraClip implantation. Our CMR findings indicate that percutaneous mitral valve repair results in reverse LV but not in RV or LA remodeling.

KEY POINTS: • Volume measurements by cardiovascular magnetic resonance imaging are feasible following percutaneous mitral valve repair despite device-related artifacts.• A significant reduction of left ventricular volume was found in terms of beneficial, reverse left ventricular remodeling after 6-month follow-up.• No significant reduction was found in right ventricular or left atrial volumes after percutaneous mitral valve repair after 6-month follow-up.

Original language	English
Journal	RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Volume	186
Issue number	10
Pages (from-to)	951-8
Number of pages	8
DOIs	https://doi.org/10.1055/s-0034-1366216
Publication status	Published - Oct 2014

Keywords

Artifacts
Cardiac Catheterization
Cardiac Volume
Echocardiography
Equipment Design
Feasibility Studies
Female
Follow-Up Studies
Heart Atria
Heart Ventricles
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine
Male
Minimally Invasive Surgical Procedures
Mitral Valve
Mitral Valve Insufficiency
Postoperative Complications
Surgical Instruments
Ventricular Remodeling

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10.1055/s-0034-1366216

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Radunski, U. K., Franzen, O., Barmeyer, A., Lange, M., Lund, G., Rudolph, V., Schlüter, M., Adam, G., Reichenspurner, H., Blankenberg, S., Baldus, S., & Muellerleile, K. (2014). Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging. RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin, 186(10), 951-8. https://doi.org/10.1055/s-0034-1366216

Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging. / Radunski, U K; Franzen, O; Barmeyer, A et al.
In: RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin, Vol. 186, No. 10, 10.2014, p. 951-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Radunski, UK, Franzen, O, Barmeyer, A, Lange, M, Lund, G, Rudolph, V, Schlüter, M, Adam, G, Reichenspurner, H, Blankenberg, S, Baldus, S & Muellerleile, K 2014, 'Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging', RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin, vol. 186, no. 10, pp. 951-8. https://doi.org/10.1055/s-0034-1366216

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title = "Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging",

abstract = "PURPOSE: Percutaneous mitral valve repair with the MitraClip device (Abbott Vascular, Redwood City, California, USA) is a novel therapeutic option in patients with mitral regurgitation. This study evaluated the feasibility of cardiac volume measurements by cardiovascular magnetic resonance imaging (CMR) to assess reverse myocardial remodeling in patients after MitraClip implantation.MATERIALS AND METHODS: 12 patients underwent CMR at baseline (BL) before and at 6 months follow-up (FU) after MitraClip implantation. Cine-CMR was performed in short- and long-axes for the assessment of left ventricular (LV), right ventricular (RV) and left atrial (LA) volumes.RESULTS: Assessment of endocardial contours was not compromised by the device-related artifact. No significant differences in observer variances were observed for LV, RV and LA volume measurements between BL and FU. LV end-diastolic (median 127 [IQR 96 - 150] vs. 112 [86 - 150] ml/m(2); p = 0.03) and LV end-systolic (82 [54 - 91] vs. 69 [48 - 99] ml/m(2); p = 0.03) volume indices decreased significantly from BL to FU. No significant differences were found for RV end-diastolic (94 [75 - 103] vs. 99 [77 - 123] ml/m(2); p = 0.91), RV end-systolic (48 [42 - 80] vs. 51 [40 - 81] ml/m(2); p = 0.48), and LA (87 [55 - 124] vs. 92 [48 - 137] ml/m(2); p = 0.20) volume indices between BL and FU.CONCLUSION: CMR enables the assessment of cardiac volumes in patients after MitraClip implantation. Our CMR findings indicate that percutaneous mitral valve repair results in reverse LV but not in RV or LA remodeling.KEY POINTS: • Volume measurements by cardiovascular magnetic resonance imaging are feasible following percutaneous mitral valve repair despite device-related artifacts.• A significant reduction of left ventricular volume was found in terms of beneficial, reverse left ventricular remodeling after 6-month follow-up.• No significant reduction was found in right ventricular or left atrial volumes after percutaneous mitral valve repair after 6-month follow-up.",

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author = "Radunski, \{U K\} and O Franzen and A Barmeyer and M Lange and G Lund and V Rudolph and M Schl{\"u}ter and G Adam and H Reichenspurner and S Blankenberg and S Baldus and K Muellerleile",

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year = "2014",

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doi = "10.1055/s-0034-1366216",

language = "English",

volume = "186",

pages = "951--8",

journal = "R{\"o}Fo : Fortschritte auf dem Gebiete der R{\"o}ntgenstrahlen und der Nuklearmedizin",

issn = "1438-9010",

publisher = "GeorgThieme Verlag",

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TY - JOUR

T1 - Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging

AU - Radunski, U K

AU - Franzen, O

AU - Barmeyer, A

AU - Lange, M

AU - Lund, G

AU - Rudolph, V

AU - Schlüter, M

AU - Adam, G

AU - Reichenspurner, H

AU - Blankenberg, S

AU - Baldus, S

AU - Muellerleile, K

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2014/10

Y1 - 2014/10

N2 - PURPOSE: Percutaneous mitral valve repair with the MitraClip device (Abbott Vascular, Redwood City, California, USA) is a novel therapeutic option in patients with mitral regurgitation. This study evaluated the feasibility of cardiac volume measurements by cardiovascular magnetic resonance imaging (CMR) to assess reverse myocardial remodeling in patients after MitraClip implantation.MATERIALS AND METHODS: 12 patients underwent CMR at baseline (BL) before and at 6 months follow-up (FU) after MitraClip implantation. Cine-CMR was performed in short- and long-axes for the assessment of left ventricular (LV), right ventricular (RV) and left atrial (LA) volumes.RESULTS: Assessment of endocardial contours was not compromised by the device-related artifact. No significant differences in observer variances were observed for LV, RV and LA volume measurements between BL and FU. LV end-diastolic (median 127 [IQR 96 - 150] vs. 112 [86 - 150] ml/m(2); p = 0.03) and LV end-systolic (82 [54 - 91] vs. 69 [48 - 99] ml/m(2); p = 0.03) volume indices decreased significantly from BL to FU. No significant differences were found for RV end-diastolic (94 [75 - 103] vs. 99 [77 - 123] ml/m(2); p = 0.91), RV end-systolic (48 [42 - 80] vs. 51 [40 - 81] ml/m(2); p = 0.48), and LA (87 [55 - 124] vs. 92 [48 - 137] ml/m(2); p = 0.20) volume indices between BL and FU.CONCLUSION: CMR enables the assessment of cardiac volumes in patients after MitraClip implantation. Our CMR findings indicate that percutaneous mitral valve repair results in reverse LV but not in RV or LA remodeling.KEY POINTS: • Volume measurements by cardiovascular magnetic resonance imaging are feasible following percutaneous mitral valve repair despite device-related artifacts.• A significant reduction of left ventricular volume was found in terms of beneficial, reverse left ventricular remodeling after 6-month follow-up.• No significant reduction was found in right ventricular or left atrial volumes after percutaneous mitral valve repair after 6-month follow-up.

AB - PURPOSE: Percutaneous mitral valve repair with the MitraClip device (Abbott Vascular, Redwood City, California, USA) is a novel therapeutic option in patients with mitral regurgitation. This study evaluated the feasibility of cardiac volume measurements by cardiovascular magnetic resonance imaging (CMR) to assess reverse myocardial remodeling in patients after MitraClip implantation.MATERIALS AND METHODS: 12 patients underwent CMR at baseline (BL) before and at 6 months follow-up (FU) after MitraClip implantation. Cine-CMR was performed in short- and long-axes for the assessment of left ventricular (LV), right ventricular (RV) and left atrial (LA) volumes.RESULTS: Assessment of endocardial contours was not compromised by the device-related artifact. No significant differences in observer variances were observed for LV, RV and LA volume measurements between BL and FU. LV end-diastolic (median 127 [IQR 96 - 150] vs. 112 [86 - 150] ml/m(2); p = 0.03) and LV end-systolic (82 [54 - 91] vs. 69 [48 - 99] ml/m(2); p = 0.03) volume indices decreased significantly from BL to FU. No significant differences were found for RV end-diastolic (94 [75 - 103] vs. 99 [77 - 123] ml/m(2); p = 0.91), RV end-systolic (48 [42 - 80] vs. 51 [40 - 81] ml/m(2); p = 0.48), and LA (87 [55 - 124] vs. 92 [48 - 137] ml/m(2); p = 0.20) volume indices between BL and FU.CONCLUSION: CMR enables the assessment of cardiac volumes in patients after MitraClip implantation. Our CMR findings indicate that percutaneous mitral valve repair results in reverse LV but not in RV or LA remodeling.KEY POINTS: • Volume measurements by cardiovascular magnetic resonance imaging are feasible following percutaneous mitral valve repair despite device-related artifacts.• A significant reduction of left ventricular volume was found in terms of beneficial, reverse left ventricular remodeling after 6-month follow-up.• No significant reduction was found in right ventricular or left atrial volumes after percutaneous mitral valve repair after 6-month follow-up.

KW - Artifacts

KW - Cardiac Catheterization

KW - Cardiac Volume

KW - Echocardiography

KW - Equipment Design

KW - Feasibility Studies

KW - Female

KW - Follow-Up Studies

KW - Heart Atria

KW - Heart Ventricles

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Minimally Invasive Surgical Procedures

KW - Mitral Valve

KW - Mitral Valve Insufficiency

KW - Postoperative Complications

KW - Surgical Instruments

KW - Ventricular Remodeling

UR - https://www.scopus.com/pages/publications/84910006735

U2 - 10.1055/s-0034-1366216

DO - 10.1055/s-0034-1366216

M3 - Journal article

C2 - 24648233

SN - 1438-9010

VL - 186

SP - 951

EP - 958

JO - RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin

JF - RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin

IS - 10

ER -

Cardiac remodeling following percutaneous mitral valve repair - initial results assessed by cardiovascular magnetic resonance imaging

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Keywords

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