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Cardiac natriuretic Peptide gene expression and plasma concentrations during the first 72 hours of life in piglets

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Plasma measurement of cardiac natriuretic peptides constitutes promising markers of congenital heart disease. However, concentrations change rapidly and dramatically during the first days after delivery even in healthy neonates, which complicates clinical interpretation. It is unknown whether these changes in plasma concentrations are explained by corresponding changes in the cardiac gene expression. We quantified the chamber-specific mRNA levels of ANP (A-type natriuretic peptide) and BNP (B-type natriuretic peptide) and plasma pro-ANP and BNP-32 concentrations in healthy piglets during the first 72 hours of life (from 2 litters, n = 44). Chamber-specific ANP and BNP mRNA levels reflected hemodynamic neonate changes at birth but did not correlate with circulating natriuretic peptide concentrations. However, plasma pro-ANP and creatinine concentrations were closely correlated (P
Original languageEnglish
JournalEndocrinology
Volume154
Issue number5
Pages (from-to)1864-72
Number of pages9
ISSN0013-7227
DOIs
Publication statusPublished - May 2013

    Research areas

  • Animals, Animals, Newborn, Atrial Natriuretic Factor, Coronary Circulation, Echocardiography, Female, Fetal Blood, Gene Expression, Male, Myocardium, Natriuretic Peptide, Brain, Osmolar Concentration, Pregnancy, Swine, Time Factors

ID: 41369246