Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The use of matrigel has no influence on tumor development or PET imaging in FaDu human head and neck cancer xenografts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. 3D facial landmarks: Inter-operator variability of manual annotation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Area of ischemia assessed by physicians and software packages from myocardial perfusion scintigrams

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Left ventricular mass (LVM) is an independent risk factor for the prediction of cardiac events. Its assessment is a clinically important diagnostic procedure in cardiology and may be performed by Computed Tomography (CT). The aim of this study was to assess the correlation between the cardiac left ventricular shell volume (LVShV) determined by postmortem Computed Tomography (PMCT) and the anatomic LVM obtained at autopsy and to calculate the myocardial tissue density.

METHODS: A total of 109 deceased individuals were examined with a 64-slice CT scanner and LVShV was determined. At autopsy, the left ventricle was dissected and weighted. The correlation between LVShV and the anatomic LVM was analysed. Asymmetric left ventricular (LV) hypertrophy was recorded. Inter-observer variability was evaluated, and a density value for myocardial tissue was calculated.

RESULTS: The mean age of the deceased was 55 ± 16 years, and 58% was men. We found 30 cases of asymmetric LV hypertrophy. A highly positive correlation existed between LVShV and anatomic LVM (r = 0.857; p < 0.0001), regardless of hypertrophy, asymmetric hypertrophy and gender. The mean difference in the inter-observer variability for LVShV assessment was - 4.4 ml (95% CI: -26.4; 17.6). A linear regression analysis was performed, resulting in a value of 1.265 g/ml for myocardial tissue density. Applying the hitherto used myocardial tissue density of 1.055 g/ml underestimated the anatomic LVM by 18.1% (p < 0.0001).

CONCLUSION: PMCT is a helpful tool for the assessment of LVM, and LVShV is highly correlated with LVM as assessed by subsequent autopsy. The correlation between the two was independent of gender, hypertrophy and LV asymmetric hypertrophy. We found a higher myocardial tissue density of 1.265 g/ml compared to previous studies. We show that PMCT combined with autopsy may contribute not only to anatomical but also clinical knowledge.

Original languageEnglish
JournalBMC Medical Imaging
Volume19
Issue number1
Pages (from-to)29
ISSN1471-2342
DOIs
Publication statusPublished - 12 Apr 2019

    Research areas

  • Adult, Aged, Aged, 80 and over, Autopsy/methods, Female, Humans, Hypertrophy, Left Ventricular/diagnosis, Linear Models, Male, Middle Aged, Observer Variation, Prospective Studies, Tomography, X-Ray Computed/instrumentation, Young Adult

ID: 58358279