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Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers

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Breath-hold divers (BHD) enduring apnea for more than 4 min are characterized by resistance to release of reactive oxygen species, reduced sensitivity to hypoxia, and low mitochondrial oxygen consumption in their skeletal muscles similar to northern elephant seals. The muscles and myocardium of harbor seals also exhibit metabolic adaptations including increased cardiac lactate-dehydrogenase-activity, exceeding their hypoxic limit. We hypothesized that the myocardium of BHD possesses similar adaptive mechanisms. During maximum apnea 15O-H2O-PET/CT (n = 6) revealed no myocardial perfusion deficits but increased myocardial blood flow (MBF). Cardiac MRI determined blood oxygen level dependence oxygenation (n = 8) after 4 min of apnea was unaltered compared to rest, whereas cine-MRI demonstrated increased left ventricular wall thickness (LVWT). Arterial blood gases were collected after warm-up and maximum apnea in a pool. At the end of the maximum pool apnea (5 min), arterial saturation decreased to 52%, and lactate decreased 20%. Our findings contrast with previous MR studies of BHD, that reported elevated cardiac troponins and decreased myocardial perfusion after 4 min of apnea. In conclusion, we demonstrated for the first time with 15O-H2O-PET/CT and MRI in elite BHD during maximum apnea, that MBF and LVWT increases while lactate decreases, indicating anaerobic/fat-based cardiac-metabolism similar to diving mammals.

Original languageEnglish
Article number2545
JournalScientific Reports
Volume11
Issue number1
Pages (from-to)2545
ISSN2045-2322
DOIs
Publication statusPublished - 28 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

    Research areas

  • Adaptation, Physiological, Adult, Apnea/metabolism, Blood Gas Analysis, Blood Pressure, Breath Holding, Diving, Female, Heart Rate, Hemodynamics, Humans, Hypoxia/metabolism, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium/metabolism, Positron Emission Tomography Computed Tomography

ID: 71923034