TY - JOUR
T1 - Cardiac findings in newborn twins
AU - Molin, Julie
AU - Paerregaard, Maria Munk
AU - Pihl, Christian
AU - Thygesen, Caroline Boye
AU - Pietersen, Adrian
AU - Dannesbo, Sofie
AU - Norsk, Jakob Boesgaard
AU - Raja, Anna Axelsson
AU - Vøgg, Ruth Ottilia B
AU - Sillesen, Anne-Sophie
AU - Iversen, Kasper Karmark
AU - Bundgaard, Henning
AU - Christensen, Alex Hørby
N1 - This article is protected by copyright. All rights reserved.
PY - 2023/10
Y1 - 2023/10
N2 - AIMS: To evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.METHODS: Prospective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.RESULTS: We included 412 newborn twins (16% monochorionic; 50% boys) and 1,236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non-severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p=0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p=0.04), higher heart rate (148 vs. 144 bpm, p=0.04), more left-shifted QRS axis (106 vs. 111°, p<0.001), and lower maximum R-wave amplitude in V1 (927 vs. 1,015 μV, p=0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p<0.05).CONCLUSION: Despite contemporary surveillance, we found an increased prevalence of non-severe structural heart disease in a population-based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.
AB - AIMS: To evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.METHODS: Prospective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.RESULTS: We included 412 newborn twins (16% monochorionic; 50% boys) and 1,236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non-severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p=0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p=0.04), higher heart rate (148 vs. 144 bpm, p=0.04), more left-shifted QRS axis (106 vs. 111°, p<0.001), and lower maximum R-wave amplitude in V1 (927 vs. 1,015 μV, p=0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p<0.05).CONCLUSION: Despite contemporary surveillance, we found an increased prevalence of non-severe structural heart disease in a population-based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.
KW - congenital heart disease
KW - ECG
KW - echocardiography
KW - multiple pregnancy
KW - Heart
KW - Prevalence
KW - Prospective Studies
KW - Humans
KW - Male
KW - Heart Diseases
KW - Female
KW - Twins
KW - Infant, Newborn
UR - http://www.scopus.com/inward/record.url?scp=85145028669&partnerID=8YFLogxK
U2 - 10.1111/apa.16626
DO - 10.1111/apa.16626
M3 - Journal article
C2 - 36513612
SN - 1651-2227
VL - 112
SP - 2050
EP - 2059
JO - Acta paediatrica
JF - Acta paediatrica
IS - 10
ER -