TY - JOUR
T1 - Cardiac Characteristics of Hospitalized Influenza Patients
T2 - An Interim Analysis From the FluHeart Study
AU - Skaarup, Kristoffer Grundtvig
AU - Davidovski, Filip Soeskov
AU - Durukan, Emil
AU - Modin, Daniel
AU - Lassen, Mats Christian Højbjerg
AU - Dons, Maria
AU - Jensen, Anne Marie Reimer
AU - Johansen, Niklas Dyrby
AU - Sengeløv, Morten
AU - Vyff, Frederikke
AU - Landler, Nino Emanuel
AU - Jensen, Gorm Boje
AU - Nielsen, Anne Bjerg
AU - Christensen, Jacob
AU - Hauser, Raphael
AU - Schnohr, Peter
AU - Møgelvang, Rasmus
AU - Nielsen, Lene
AU - Jensen, Jens-Ulrik Stæhr
AU - Biering-Sørensen, Tor
N1 - © 2025 The Author(s). Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
PY - 2025/2/19
Y1 - 2025/2/19
N2 - BACKGROUND: Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza infection on cardiac structure and function as assessed by echocardiography during hospitalization.METHODS: This prospective cohort study included hospitalized influenza patients of the 2021-2022 influenza season. Participants underwent echocardiography using a prespecified protocol. Participants were successfully matched 1:1:1 on age, sex, and heart failure status with controls from the general population and controls hospitalized with COVID-19.RESULTS: This interim analysis involved 108 participants (36 influenza patients, 36 general population controls, and 36 COVID-19 patients). Mean age was 72 ± 18 years and 58% were male. Median time from admission to echocardiography was 1 day (IQI: 1:1) for influenza patients. The prevalence of left ventricular (LV) dysfunction was 75%, and right ventricular (RV) dysfunction was observed in 20% of influenza patients. N-terminal pro-brain natriuretic peptide levels were elevated ≥ 300 pg/mL in 62%, and 19% exhibited myocardial injury with elevated high-sensitivity troponin I levels. RV tricuspid annular plane systolic excursion and LV early diastolic peak mitral inflow to early diastolic tissue velocity were significantly worse in influenza patients compared to general population controls. Echocardiographic measures did not significantly differ between patients hospitalized with influenza and COVID-19.CONCLUSION: In this interim analysis of the FluHeart study, both RV and LV function measures were significantly impaired in hospitalized influenza patients compared with matched general population controls. The extent of impairment resembled that observed in hospitalized COVID-19 patients.
AB - BACKGROUND: Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza infection on cardiac structure and function as assessed by echocardiography during hospitalization.METHODS: This prospective cohort study included hospitalized influenza patients of the 2021-2022 influenza season. Participants underwent echocardiography using a prespecified protocol. Participants were successfully matched 1:1:1 on age, sex, and heart failure status with controls from the general population and controls hospitalized with COVID-19.RESULTS: This interim analysis involved 108 participants (36 influenza patients, 36 general population controls, and 36 COVID-19 patients). Mean age was 72 ± 18 years and 58% were male. Median time from admission to echocardiography was 1 day (IQI: 1:1) for influenza patients. The prevalence of left ventricular (LV) dysfunction was 75%, and right ventricular (RV) dysfunction was observed in 20% of influenza patients. N-terminal pro-brain natriuretic peptide levels were elevated ≥ 300 pg/mL in 62%, and 19% exhibited myocardial injury with elevated high-sensitivity troponin I levels. RV tricuspid annular plane systolic excursion and LV early diastolic peak mitral inflow to early diastolic tissue velocity were significantly worse in influenza patients compared to general population controls. Echocardiographic measures did not significantly differ between patients hospitalized with influenza and COVID-19.CONCLUSION: In this interim analysis of the FluHeart study, both RV and LV function measures were significantly impaired in hospitalized influenza patients compared with matched general population controls. The extent of impairment resembled that observed in hospitalized COVID-19 patients.
KW - Humans
KW - Male
KW - Female
KW - Influenza, Human/complications
KW - Aged
KW - Prospective Studies
KW - Hospitalization
KW - Middle Aged
KW - Echocardiography
KW - COVID-19/complications
KW - Aged, 80 and over
KW - SARS-CoV-2
KW - Ventricular Dysfunction, Left/physiopathology
KW - Ventricular Dysfunction, Right/physiopathology
KW - Natriuretic Peptide, Brain/blood
UR - http://www.scopus.com/inward/record.url?scp=85218267219&partnerID=8YFLogxK
U2 - 10.1111/irv.70067
DO - 10.1111/irv.70067
M3 - Journal article
C2 - 39965617
SN - 1750-2640
VL - 19
JO - Influenza and other Respiratory Viruses
JF - Influenza and other Respiratory Viruses
IS - 2
M1 - e70067
ER -