Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

K Almstrup; J E Nielsen; O Mlynarska; M T Jansen; A Jørgensen; N E Skakkebæk; E Rajpert-De Meyts

doi:10.1038/sj.bjc.6605880

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

K Almstrup, J E Nielsen, O Mlynarska, M T Jansen, A Jørgensen, N E Skakkebæk, E Rajpert-De Meyts

Department of Growth and Reproduction

78 Citations (Scopus)

Abstract

The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

Original language	English
Journal	British Journal of Cancer
Volume	103
Issue number	8
Pages (from-to)	1269-76
Number of pages	8
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6605880
Publication status	Published - 12 Oct 2010

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title = "Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells",

abstract = "The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.",

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T1 - Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

AU - Almstrup, K

AU - Nielsen, J E

AU - Mlynarska, O

AU - Jansen, M T

AU - Jørgensen, A

AU - Skakkebæk, N E

AU - Rajpert-De Meyts, E

PY - 2010/10/12

Y1 - 2010/10/12

N2 - The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

AB - The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells.

UR - https://www.scopus.com/pages/publications/77957984879

U2 - 10.1038/sj.bjc.6605880

DO - 10.1038/sj.bjc.6605880

M3 - Journal article

C2 - 20823885

SN - 0007-0920

VL - 103

SP - 1269

EP - 1276

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

Abstract

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