Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

Daniella Bach Pedersen; Peter Koch Jensen; Morten la Cour; Jens Folke Kiilgaard; Thor Eysteinsson; Kurt Bang; Anne  Wiencke; Einar Stefánsson

doi:10.1007/s00417-003-0817-3

Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

Daniella Bach Pedersen, Peter Koch Jensen, Morten la Cour, Jens Folke Kiilgaard, Thor Eysteinsson, Kurt Bang, Anne Wiencke, Einar Stefánsson

Department of Ophthalmology

58 Citations (Scopus)

Abstract

Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied.

Original language	English
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	243
Issue number	2
Pages (from-to)	163-8
Number of pages	6
ISSN	0721-832X
DOIs	https://doi.org/10.1007/s00417-003-0817-3
Publication status	Published - 2005

Keywords

Animals
Carbonic Anhydrase Inhibitors
Carbonic Anhydrases
Injections, Intravenous
Ion-Selective Electrodes
Optic Nerve
Oxygen
Partial Pressure
Polarography
Retina
Retinal Vessels
Sulfonamides
Swine
Thiophenes
Vasodilation

Access to Document

10.1007/s00417-003-0817-3

Cite this

@article{007ae90817ca44bfb75e089528fff7bf,

title = "Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels",

abstract = "Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied.",

keywords = "Animals, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Injections, Intravenous, Ion-Selective Electrodes, Optic Nerve, Oxygen, Partial Pressure, Polarography, Retina, Retinal Vessels, Sulfonamides, Swine, Thiophenes, Vasodilation",

author = "Pedersen, \{Daniella Bach\} and \{Koch Jensen\}, Peter and \{la Cour\}, Morten and Kiilgaard, \{Jens Folke\} and Thor Eysteinsson and Kurt Bang and Anne Wiencke and Einar Stef{\'a}nsson",

year = "2005",

doi = "10.1007/s00417-003-0817-3",

language = "English",

volume = "243",

pages = "163--8",

journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",

issn = "0721-832X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

AU - Pedersen, Daniella Bach

AU - Koch Jensen, Peter

AU - la Cour, Morten

AU - Kiilgaard, Jens Folke

AU - Eysteinsson, Thor

AU - Bang, Kurt

AU - Wiencke, Anne

AU - Stefánsson, Einar

PY - 2005

Y1 - 2005

N2 - Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied.

AB - Carbonic anhydrase inhibitors (CAIs) increase blood flow in the brain and probably also in the optic nerve and retina. Additionally they elevate the oxygen tension in the optic nerve in the pig. We propose that they also raise the oxygen tension in the retina. We studied the oxygen tension in the pig retina and optic nerve before and after dorzolamide injection. Also the retinal vessel diameters during carbonic anhydrase inhibition were studied.

KW - Animals

KW - Carbonic Anhydrase Inhibitors

KW - Carbonic Anhydrases

KW - Injections, Intravenous

KW - Ion-Selective Electrodes

KW - Optic Nerve

KW - Oxygen

KW - Partial Pressure

KW - Polarography

KW - Retina

KW - Retinal Vessels

KW - Sulfonamides

KW - Swine

KW - Thiophenes

KW - Vasodilation

UR - https://www.scopus.com/pages/publications/14944366770

U2 - 10.1007/s00417-003-0817-3

DO - 10.1007/s00417-003-0817-3

M3 - Journal article

C2 - 15742212

SN - 0721-832X

VL - 243

SP - 163

EP - 168

JO - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

IS - 2

ER -

Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this