Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Danish Scale for visual rating of massive weight loss body contours. Conceptualization and construct

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Patient-and observer-reported long-term scar quality of wide local excision scars in melanoma patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. ICG angiography in immediate and delayed autologous breast reconstructions: peroperative evaluation and postoperative outcomes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Laser-assisted indocyanine green angiography in implant-based immediate breast reconstruction: a retrospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A core undergraduate curriculum in plastic surgery - a Delphi consensus study in Scandinavia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reliable test of clinicians' mastery in skin cancer diagnostics

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Moving breast implant registries forward: Are they FAIR and Functional?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High-end versus Low-end Thermal Imaging for Detection of Arterial Perforators

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Extramammary Paget's Disease and Melanoma: 2 Cases of Double Cancers

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Radiation is considered to be a risk factor for developing capsular contracture in augmented women, but the studies reporting on this subject show conflicting results. In this systematic review we sought to understand the risk of capsular contracture in augmented patients with breast cancer treated with breast conserving surgery and radiotherapy. A search was conducted through PubMed for studies reporting on breast cancer, breast augmentation and radiotherapy, with capsular contracture as our primary outcome. To determine if specific risk factors were significant predictors of the development of capsular contracture, we performed uni- and multivariate analysis. Our search revealed 136 articles, of which 12 were deemed eligible. A total of 237 patients were included in the analysis. Univariate analysis revealed that whole breast irradiation (WBI) was significantly associated with a higher risk of contracture (p < .001), compared to treatment with accelerated partial breast irradiation (APBI). A higher radiotherapy dose regimen was also significantly associated with a risk of capsular contracture (p < .001). When performing the multivariate analysis only the effect of increasing radiation dose remained significant (p < .05). Neither the implant location nor the age of the implant had any significant effect on the development of contracture. In conclusion this review shows that WBI is associated with a higher risk of contracture compared to treatment with APBI. Because of the limitations of the studies included, further studies with larger patient cohorts are needed to establish this correlation and evaluate other potential risk factors.

Original languageEnglish
JournalJournal of Plastic Surgery and Hand Surgery
Volume54
Issue number4
Pages (from-to)225-232
Number of pages8
ISSN2000-656X
DOIs
Publication statusPublished - Aug 2020

ID: 61930350