Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Anders Rørbaek Madsen; Maria G Gundgaard; Camilla M Hoff; Christian Maare; Peter Holmboe; Marianne Knap; Lone L Thomsen; Christian Buchwald; Hanne S Hansen; Poul Bretlau; Cai Grau

doi:10.1002/hed.20877

Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Anders Rørbaek Madsen, Maria G Gundgaard, Camilla M Hoff, Christian Maare, Peter Holmboe, Marianne Knap, Lone L Thomsen, Christian Buchwald, Hanne S Hansen, Poul Bretlau, Cai Grau

73 Citations (Scopus)

Abstract

BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.

METHODS: Review of 68 consecutive cases: 47 squamous cell carcinoma, 10 basal cell carcinoma, and 11 other histologies. Moody (modified Pittsburgh) stages were T1 (26), T2 (9), T3 (8), T4 (23), Tx (2). Sixty-four patients were treated with curative intent: 24 primary radiotherapy, 18 primary surgery, and 22 combined. Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.

RESULTS: Twenty-seven of 28 recurrences involved primary site. Kaplan-Meier analysis showed 5-year locoregional control of 48%, disease-specific survival 57%, and overall survival 44%.

CONCLUSION: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.

Original language	English
Journal	Head and Neck
Volume	30
Issue number	10
Pages (from-to)	1332-8
Number of pages	7
ISSN	1043-3074
DOIs	https://doi.org/10.1002/hed.20877
Publication status	Published - Oct 2008
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma/pathology
Child
Denmark
Ear Canal
Ear Neoplasms/pathology
Ear, Middle
Female
Humans
Kaplan-Meier Estimate
Male
Medical Records
Middle Aged
Neoplasm Recurrence, Local/prevention & control
Neoplasm Staging
Prognosis
Retrospective Studies
Temporal Bone/pathology
Treatment Outcome
Young Adult

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10.1002/hed.20877

Cite this

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title = "Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001",

abstract = "BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.METHODS: Review of 68 consecutive cases: 47 squamous cell carcinoma, 10 basal cell carcinoma, and 11 other histologies. Moody (modified Pittsburgh) stages were T1 (26), T2 (9), T3 (8), T4 (23), Tx (2). Sixty-four patients were treated with curative intent: 24 primary radiotherapy, 18 primary surgery, and 22 combined. Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.RESULTS: Twenty-seven of 28 recurrences involved primary site. Kaplan-Meier analysis showed 5-year locoregional control of 48\%, disease-specific survival 57\%, and overall survival 44\%.CONCLUSION: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma/pathology, Child, Denmark, Ear Canal, Ear Neoplasms/pathology, Ear, Middle, Female, Humans, Kaplan-Meier Estimate, Male, Medical Records, Middle Aged, Neoplasm Recurrence, Local/prevention \& control, Neoplasm Staging, Prognosis, Retrospective Studies, Temporal Bone/pathology, Treatment Outcome, Young Adult",

author = "Madsen, \{Anders R{\o}rbaek\} and Gundgaard, \{Maria G\} and Hoff, \{Camilla M\} and Christian Maare and Peter Holmboe and Marianne Knap and Thomsen, \{Lone L\} and Christian Buchwald and Hansen, \{Hanne S\} and Poul Bretlau and Cai Grau",

year = "2008",

month = oct,

doi = "10.1002/hed.20877",

language = "English",

volume = "30",

pages = "1332--8",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

AU - Madsen, Anders Rørbaek

AU - Gundgaard, Maria G

AU - Hoff, Camilla M

AU - Maare, Christian

AU - Holmboe, Peter

AU - Knap, Marianne

AU - Thomsen, Lone L

AU - Buchwald, Christian

AU - Hansen, Hanne S

AU - Bretlau, Poul

AU - Grau, Cai

PY - 2008/10

Y1 - 2008/10

N2 - BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.METHODS: Review of 68 consecutive cases: 47 squamous cell carcinoma, 10 basal cell carcinoma, and 11 other histologies. Moody (modified Pittsburgh) stages were T1 (26), T2 (9), T3 (8), T4 (23), Tx (2). Sixty-four patients were treated with curative intent: 24 primary radiotherapy, 18 primary surgery, and 22 combined. Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.RESULTS: Twenty-seven of 28 recurrences involved primary site. Kaplan-Meier analysis showed 5-year locoregional control of 48%, disease-specific survival 57%, and overall survival 44%.CONCLUSION: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.

AB - BACKGROUND: In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival.METHODS: Review of 68 consecutive cases: 47 squamous cell carcinoma, 10 basal cell carcinoma, and 11 other histologies. Moody (modified Pittsburgh) stages were T1 (26), T2 (9), T3 (8), T4 (23), Tx (2). Sixty-four patients were treated with curative intent: 24 primary radiotherapy, 18 primary surgery, and 22 combined. Surgery was limited to tumor excision and mastoidectomy and in 1 case temporal bone excision.RESULTS: Twenty-seven of 28 recurrences involved primary site. Kaplan-Meier analysis showed 5-year locoregional control of 48%, disease-specific survival 57%, and overall survival 44%.CONCLUSION: This nationwide study confirmed that local failure is the main problem, and future improvements should focus on more aggressive local treatment.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma/pathology

KW - Child

KW - Denmark

KW - Ear Canal

KW - Ear Neoplasms/pathology

KW - Ear, Middle

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Medical Records

KW - Middle Aged

KW - Neoplasm Recurrence, Local/prevention & control

KW - Neoplasm Staging

KW - Prognosis

KW - Retrospective Studies

KW - Temporal Bone/pathology

KW - Treatment Outcome

KW - Young Adult

UR - https://www.scopus.com/pages/publications/55549146801

U2 - 10.1002/hed.20877

DO - 10.1002/hed.20877

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SP - 1332

EP - 1338

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001

Abstract

Keywords

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