Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Continuous focus on preventive strategies and follow-up is important for a change

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Changing incidence of obstetric anal sphincter injuries - a result of formal prevention programs?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An audit on a routine antenatal nonstress testing program in pregnant women with preexisting diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Targeted Rhesus immunoglobulin for RhD negative women undergoing an induced abortion: a clinical pilot study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Polygenic predisposition to breast cancer and the risk of coronary artery disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of the H1-antihistamine clemastine on PACAP38 induced migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To establish reference intervals for cancer antigen 125 (CA-125) in women with expected normal pregnancy, delivery, and early postpartum period.

DESIGN: Prospective observational study.

SETTING: Department of Clinical Biochemistry and Obstetrics, Copenhagen University Hospital, Gentofte, Denmark.

POPULATION: Eight hundred and one women with expected normal pregnancies were investigated. Of these, 640 delivered vaginally, 82 by emergency cesarean section, and 79 by elective cesarean section; 720 women had uncomplicated pregnancies.

METHODS: Samples were collected at gestational weeks 13-20, 21-28, 29-34, 35-42, during labor, and on first and second day postpartum. Reference intervals were calculated for each gestational period as recommended by the International Federation of Clinical Chemistry and Laboratory Medicine.

MAIN OUTCOME MEASURES: Concentration of serum CA-125 during the gestational period and around delivery.

RESULTS: CA-125 was fairly stable below 35 U/mL during pregnancy but increased markedly during vaginal delivery, to a minor degree during emergency cesarean section, and only slightly during elective cesarean section. In the early postpartum period, CA-125 decreased with an apparent half-life of 24 h.

CONCLUSIONS: The CA-125 cut-off value (<35 U/mL) used for non-pregnant women can be used for women during pregnancy after gestational week 13 as a supplement to ultrasound evaluation of ovarian cysts. The wide range of CA-125 concentration during normal pregnancies makes it unlikely that small fluctuations in CA-125 can be clinically useful for identifying other conditions. Measuring CA-125 around the time of delivery is not recommended. Gestational age-specific reference intervals during normal pregnancy are not needed.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume93
Issue number12
Pages (from-to)1295-301
Number of pages7
ISSN0001-6349
DOIs
Publication statusPublished - Dec 2014

    Research areas

  • Adult, Biological Markers, CA-125 Antigen, Cohort Studies, Denmark, Female, Humans, Postpartum Period, Pregnancy, Pregnancy Outcome, Pregnancy Trimesters, Prospective Studies, Reference Values, Young Adult

ID: 44921075