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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Can Computed Tomography Perfusion Predict Treatment Response After Prostate Artery Embolization: A Feasibility Study

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  1. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

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  2. Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

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  3. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

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  4. Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2

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  1. Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

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  3. Flow Complexity Estimation in Dysfunctional Arteriovenous Dialysis Fistulas using Vector Flow Imaging

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Prostate artery embolization (PAE) is an emerging therapy for benign prostatic hyperplasia (BPH). Optimal patient selection is an important step when introducing new treatments and several characteristics associated with a good clinical outcome has previously been proposed. However, no prognostic tool is yet available for PAE. Computed tomography perfusion is an imaging technique that provides hemodynamic parameters making it possible to estimate the prostatic blood flow (PBF). This study investigated the relationship between PBF and the response to PAE. A post hoc analysis including prostate-specific antigen (PSA) measurements before and 24-h after embolization from two prospective studies on sixteen patients undergoing PAE with BPH or prostate cancer were performed. The primary outcome was the correlation between baseline PBF and the change in PSA as a surrogate measure of treatment response. Prostate volume strongly correlated with treatment response and the response was greater with incremental amounts of injected embolic material. PBF was not associated with elevation in PSA and added no information that could guide patient selection.

Original languageEnglish
JournalDiagnostics
Volume10
Issue number5
ISSN2075-4418
DOIs
Publication statusPublished - 15 May 2020

ID: 60880133