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Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?

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  1. Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Diabetes Management During Breastfeeding in Women with Type 1 Diabetes

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  3. Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

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  4. Reporting Severe Hypoglycemia in Type 1 Diabetes: Facts and Pitfalls

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  1. Impact of Meal Timing and Chronotype on Food Reward and Appetite Control in Young Adults

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  2. Role of fasting duration and weekday in incretin and glucose regulation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Type-1 diabetes and diabetic sensorimotor peripheral neuropathy does not affect the circadian rhythm of colonic contractility

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  4. Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men

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PURPOSE OF REVIEW: We reviewed published literature to determine the relationship between A1c and cardiovascular disease (CVD) and summarize the need and implications for CVD risk reduction with interventions, focusing in the prediabetic A1c range (<6.5%).

RECENT FINDINGS: Strong evidence supports a continuous relationship between A1c and CVD-even below the current levels of A1c-defined prediabetes and after adjustment for known risk factors for CVD. Clinical trials have demonstrated a reduction in CV morbidity and/or mortality when interventions are invoked in the prediabetic A1c range. Guidelines advocating CV risk factor management in prediabetes have not been widely adopted, subsequently leading to comparable coronary heart disease risk between people with prediabetes (HR = 1.9, 95% CI 1.7-2.1 vs normoglycemia) and diabetes itself (HR=2.0, 95% CI 1.8-2.2 vs no diabetes). This review highlights the missed opportunity to utilize multiple risk factor interventions to reduce CVD in high-risk people with prediabetes.

Original languageEnglish
JournalCurrent Diabetes Reports
Volume17
Issue number9
Pages (from-to)77
ISSN1534-4827
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article, Review

ID: 51623223