Calprotectin--a novel marker of obesity

Ole Hartvig Mortensen; Anders Rinnov Nielsen; Christian Erikstrup; Peter Plomgaard; Christian Philip Fischer; Rikke Krogh-Madsen; Birgitte Lindegaard; Anne Marie Petersen; Sarah Taudorf; Bente Klarlund Pedersen

doi:10.1371/journal.pone.0007419

Calprotectin--a novel marker of obesity

Ole Hartvig Mortensen, Anders Rinnov Nielsen, Christian Erikstrup, Peter Plomgaard, Christian Philip Fischer, Rikke Krogh-Madsen, Birgitte Lindegaard, Anne Marie Petersen, Sarah Taudorf, Bente Klarlund Pedersen

108 Citations (Scopus)

Abstract

BACKGROUND: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes.

METHODOLOGY/PRINCIPAL FINDINGS: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p<0.0001), whereas it did not differ between obese and non-obese patients with T2D (p = 0.62). S100A8 mRNA levels in skeletal muscle were not influenced by obesity or T2D. Multivariate regression analysis (adjusting for age, sex, smoking and HOMA2-IR) showed plasma calprotectin to be strongly associated with BMI, even when further adjusted for fitness, CRP, TNF-alpha or neutrophil number.

CONCLUSIONS/SIGNIFICANCE: Plasma calprotectin is a marker of obesity in individuals without type 2 diabetes.

Original language	English
Journal	PLoS One
Volume	4
Issue number	10
Pages (from-to)	e7419
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0007419
Publication status	Published - 12 Oct 2009

Keywords

Body Mass Index
Cross-Sectional Studies
Diabetes Mellitus, Type 2/blood
Dimerization
Female
Humans
Inflammation
Leukocyte L1 Antigen Complex/blood
Male
Middle Aged
Multivariate Analysis
Muscle, Skeletal/metabolism
Neutrophils/metabolism
Obesity/blood
Smoking

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title = "Calprotectin--a novel marker of obesity",

abstract = "BACKGROUND: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes.METHODOLOGY/PRINCIPAL FINDINGS: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p<0.0001), whereas it did not differ between obese and non-obese patients with T2D (p = 0.62). S100A8 mRNA levels in skeletal muscle were not influenced by obesity or T2D. Multivariate regression analysis (adjusting for age, sex, smoking and HOMA2-IR) showed plasma calprotectin to be strongly associated with BMI, even when further adjusted for fitness, CRP, TNF-alpha or neutrophil number.CONCLUSIONS/SIGNIFICANCE: Plasma calprotectin is a marker of obesity in individuals without type 2 diabetes.",

keywords = "Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2/blood, Dimerization, Female, Humans, Inflammation, Leukocyte L1 Antigen Complex/blood, Male, Middle Aged, Multivariate Analysis, Muscle, Skeletal/metabolism, Neutrophils/metabolism, Obesity/blood, Smoking",

author = "Mortensen, \{Ole Hartvig\} and Nielsen, \{Anders Rinnov\} and Christian Erikstrup and Peter Plomgaard and Fischer, \{Christian Philip\} and Rikke Krogh-Madsen and Birgitte Lindegaard and Petersen, \{Anne Marie\} and Sarah Taudorf and Pedersen, \{Bente Klarlund\}",

year = "2009",

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doi = "10.1371/journal.pone.0007419",

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T1 - Calprotectin--a novel marker of obesity

AU - Mortensen, Ole Hartvig

AU - Nielsen, Anders Rinnov

AU - Erikstrup, Christian

AU - Plomgaard, Peter

AU - Fischer, Christian Philip

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Petersen, Anne Marie

AU - Taudorf, Sarah

AU - Pedersen, Bente Klarlund

PY - 2009/10/12

Y1 - 2009/10/12

N2 - BACKGROUND: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes.METHODOLOGY/PRINCIPAL FINDINGS: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p<0.0001), whereas it did not differ between obese and non-obese patients with T2D (p = 0.62). S100A8 mRNA levels in skeletal muscle were not influenced by obesity or T2D. Multivariate regression analysis (adjusting for age, sex, smoking and HOMA2-IR) showed plasma calprotectin to be strongly associated with BMI, even when further adjusted for fitness, CRP, TNF-alpha or neutrophil number.CONCLUSIONS/SIGNIFICANCE: Plasma calprotectin is a marker of obesity in individuals without type 2 diabetes.

AB - BACKGROUND: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes.METHODOLOGY/PRINCIPAL FINDINGS: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p<0.0001), whereas it did not differ between obese and non-obese patients with T2D (p = 0.62). S100A8 mRNA levels in skeletal muscle were not influenced by obesity or T2D. Multivariate regression analysis (adjusting for age, sex, smoking and HOMA2-IR) showed plasma calprotectin to be strongly associated with BMI, even when further adjusted for fitness, CRP, TNF-alpha or neutrophil number.CONCLUSIONS/SIGNIFICANCE: Plasma calprotectin is a marker of obesity in individuals without type 2 diabetes.

KW - Body Mass Index

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2/blood

KW - Dimerization

KW - Female

KW - Humans

KW - Inflammation

KW - Leukocyte L1 Antigen Complex/blood

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Muscle, Skeletal/metabolism

KW - Neutrophils/metabolism

KW - Obesity/blood

KW - Smoking

UR - https://www.scopus.com/pages/publications/70350719452

U2 - 10.1371/journal.pone.0007419

DO - 10.1371/journal.pone.0007419

M3 - Journal article

C2 - 19823685

SN - 1932-6203

VL - 4

SP - e7419

JO - PLoS One

JF - PLoS One

IS - 10

ER -

Calprotectin--a novel marker of obesity

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