Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Simon Hauerslev; Marie-Louise Sveen; Morten Duno; Corrado Angelini; John Vissing; Thomas O Krag

doi:10.1186/1471-2474-13-43

Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Simon Hauerslev, Marie-Louise Sveen, Morten Duno, Corrado Angelini, John Vissing, Thomas O Krag

56 Citations (Scopus)

Abstract

Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

Original language	English
Journal	B M C Musculoskeletal Disorders
Volume	13
Pages (from-to)	43-53
Number of pages	11
ISSN	1471-2474
DOIs	https://doi.org/10.1186/1471-2474-13-43
Publication status	Published - 2012

Keywords

Adolescent
Adult
Apoptosis
Biological Markers
Biopsy
Blotting, Western
Calpain
Denmark
Dystrophin
Female
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Linear Models
Male
Middle Aged
Muscle Proteins
Muscle, Skeletal
Muscular Dystrophies, Limb-Girdle
Muscular Dystrophy, Duchenne
Mutation
MyoD Protein
Myogenin
Myosin Heavy Chains
Phenotype
Proteins
Regeneration
Severity of Illness Index
Vimentin
Young Adult

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10.1186/1471-2474-13-43

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title = "Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies",

abstract = "Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.",

keywords = "Adolescent, Adult, Apoptosis, Biological Markers, Biopsy, Blotting, Western, Calpain, Denmark, Dystrophin, Female, Genetic Predisposition to Disease, Humans, Immunohistochemistry, Linear Models, Male, Middle Aged, Muscle Proteins, Muscle, Skeletal, Muscular Dystrophies, Limb-Girdle, Muscular Dystrophy, Duchenne, Mutation, MyoD Protein, Myogenin, Myosin Heavy Chains, Phenotype, Proteins, Regeneration, Severity of Illness Index, Vimentin, Young Adult",

author = "Simon Hauerslev and Marie-Louise Sveen and Morten Duno and Corrado Angelini and John Vissing and Krag, \{Thomas O\}",

year = "2012",

doi = "10.1186/1471-2474-13-43",

language = "English",

volume = "13",

pages = "43--53",

journal = "B M C Musculoskeletal Disorders",

issn = "1471-2474",

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T1 - Calpain 3 is important for muscle regeneration

T2 - evidence from patients with limb girdle muscular dystrophies

AU - Hauerslev, Simon

AU - Sveen, Marie-Louise

AU - Duno, Morten

AU - Angelini, Corrado

AU - Vissing, John

AU - Krag, Thomas O

PY - 2012

Y1 - 2012

N2 - Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

AB - Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

KW - Adolescent

KW - Adult

KW - Apoptosis

KW - Biological Markers

KW - Biopsy

KW - Blotting, Western

KW - Calpain

KW - Denmark

KW - Dystrophin

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Immunohistochemistry

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Muscle Proteins

KW - Muscle, Skeletal

KW - Muscular Dystrophies, Limb-Girdle

KW - Muscular Dystrophy, Duchenne

KW - Mutation

KW - MyoD Protein

KW - Myogenin

KW - Myosin Heavy Chains

KW - Phenotype

KW - Proteins

KW - Regeneration

KW - Severity of Illness Index

KW - Vimentin

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84858734537

U2 - 10.1186/1471-2474-13-43

DO - 10.1186/1471-2474-13-43

M3 - Journal article

C2 - 22443334

SN - 1471-2474

VL - 13

SP - 43

EP - 53

JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

ER -

Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Abstract

Keywords

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