Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cardiotoxicity in metastatic melanoma patients treated with BRAF and MEK inhibitors in a real-world setting

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genomic landscape of treatment refractory metastatic colorectal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intratumoral expression of CD38 in patients with post-transplant lymphoproliferative disorder

    Research output: Contribution to journalLetterResearchpeer-review

  4. Management of late adverse effects after chemoradiation for anal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reduction mammoplasty and mastopexy in the previously irradiated breast–a systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  2. 3D Frozen Section Histology - A Technique for Perioperative Complete Evaluation of Surgical Margins in Non-Melanoma Skin Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation

    Research output: Contribution to journalReviewResearchpeer-review

  4. Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium. Preclinical studies on calcium electroporation have shown strikingly high tumor response with cell necrosis. Calcium electroporation builds on the treatment electrochemotherapy, where chemotherapeutic drugs, mostly bleomycin, are internalized by electroporation. This double-blinded randomized study compared calcium electroporation to electrochemotherapy in terms of objective response measured 6 months after treatment.

METHODS: Seven patients with a total of 47 cutaneous metastases from breast cancer and malignant melanoma were included in the protocol. A total of 37 metastases were randomized and evaluated for response, another 10 metastases were used for biopsy. This was a non-inferiority trial and metastases were randomized individually in each patient to either intratumoral calcium or bleomycin followed by application of electric pulses to tumor site. All metastases were treated once, and after 6-months of follow-up, the randomization code was revealed.

RESULTS: Objective response of calcium electroporation was 72% (13/18) with complete response in 66% (12/18). For electrochemotherapy, objective response was 84% (16/19) with complete response in 68% (13/19). There was no statistically significant difference between the two treatments (p = 0.5). After 1 year, only three out of 25 metastases had relapsed. Ulceration, itching and exudation were reported slightly more frequently in metastases treated with bleomycin, and hyperpigmentation was only seen in metastases treated with bleomycin.

CONCLUSION: This study shows that calcium electroporation is feasible and effective in patients with cutaneous metastases.

Original languageEnglish
JournalActa oncologica
Volume57
Issue number3
Pages (from-to)311-319
Number of pages9
ISSN0284-186X
DOIs
Publication statusPublished - Mar 2018

    Research areas

  • Aged, Aged, 80 and over, Antineoplastic Agents/administration & dosage, Bleomycin/administration & dosage, Breast Neoplasms/drug therapy, Calcium/administration & dosage, Double-Blind Method, Electrochemotherapy/adverse effects, Female, Humans, Melanoma/drug therapy, Middle Aged, Skin Neoplasms/drug therapy

ID: 56582488