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Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

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DOI

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  1. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

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Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.
Original languageEnglish
JournalCephalalgia
Volume30
Issue number10
Pages (from-to)1179-86
Number of pages8
ISSN0333-1024
DOIs
Publication statusPublished - 2010

    Research areas

  • Adult, Area Under Curve, Calcitonin Gene-Related Peptide, Female, Humans, Male, Middle Aged, Migraine with Aura

ID: 32338402