C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response

P O Schiøtz; N Høiby; N Morling; H Sørensen

doi:10.1159/000152970

C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response

P O Schiøtz, N Høiby, N Morling, H Sørensen

2 Citations (Scopus)

Abstract

The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.

Original language	English
Journal	Human Heredity
Volume	28
Issue number	4
Pages (from-to)	293-300
Number of pages	8
ISSN	0001-5652
DOIs	https://doi.org/10.1159/000152970
Publication status	Published - 1978
Externally published	Yes

Keywords

Adolescent
Adult
Antibodies, Bacterial/analysis
Child
Child, Preschool
Complement C3/genetics
Cystic Fibrosis/genetics
Denmark
Female
Gene Frequency
Humans
Infant
Infant, Newborn
Male
Phenotype
Polymorphism, Genetic
Pseudomonas Infections/immunology

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10.1159/000152970

Cite this

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title = "C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response",

abstract = "The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.",

keywords = "Adolescent, Adult, Antibodies, Bacterial/analysis, Child, Child, Preschool, Complement C3/genetics, Cystic Fibrosis/genetics, Denmark, Female, Gene Frequency, Humans, Infant, Infant, Newborn, Male, Phenotype, Polymorphism, Genetic, Pseudomonas Infections/immunology",

author = "Schi{\o}tz, \{P O\} and N H{\o}iby and N Morling and H S{\o}rensen",

year = "1978",

doi = "10.1159/000152970",

language = "English",

volume = "28",

pages = "293--300",

journal = "Human Heredity",

issn = "0001-5652",

publisher = "S. Karger AG",

number = "4",

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TY - JOUR

T1 - C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response

AU - Schiøtz, P O

AU - Høiby, N

AU - Morling, N

AU - Sørensen, H

PY - 1978

Y1 - 1978

N2 - The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.

AB - The C3 types of human serum are reported for a material of 113 Danish cystic fibrosis patients, age 0-30 years. The frequency of the C3F gene was 0.2832 which was significantly higher (p less than 0.0005) than the frequency found in a control group of 224 healthy babies (C3F = 0.1585). It also differed significantly (p less than 0.01) from the C3F gene frequency of 0.1780 found in 177 blood donors, age 20-24 years. A significant association between any of the C3 phenotypes and the most serious infection in cystic fibrosis, chronic mucoid P. aeruginosa infection, or the antibody response against these bacteria was not found.

KW - Adolescent

KW - Adult

KW - Antibodies, Bacterial/analysis

KW - Child

KW - Child, Preschool

KW - Complement C3/genetics

KW - Cystic Fibrosis/genetics

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Phenotype

KW - Polymorphism, Genetic

KW - Pseudomonas Infections/immunology

UR - https://www.scopus.com/pages/publications/0017818829

U2 - 10.1159/000152970

DO - 10.1159/000152970

M3 - Journal article

C2 - 658974

SN - 0001-5652

VL - 28

SP - 293

EP - 300

JO - Human Heredity

JF - Human Heredity

IS - 4

ER -

C3 polymorphism in a Danish cystic fibrosis population and its possible association with antibody response

Abstract

Keywords

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