Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic)

Gregory Severin; Carsten H Nielsen; Andreas I Jensen; Jesper Fonslet; Andreas Kjær; Fedor Zhuravlev

doi:10.1021/acs.jmedchem.5b01167

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic)

Gregory Severin, Carsten H Nielsen, Andreas I Jensen, Jesper Fonslet, Andreas Kjær, Fedor Zhuravlev

43 Citations (Scopus)

Abstract

We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

Original language	English
Journal	Journal of Medicinal Chemistry
Volume	58
Issue number	18
Pages (from-to)	7591-5
Number of pages	5
ISSN	0022-2623
DOIs	https://doi.org/10.1021/acs.jmedchem.5b01167
Publication status	Published - 24 Sept 2015

Keywords

Animals
Antineoplastic Agents
Coordination Complexes
HT29 Cells
Humans
Mice, Nude
Positron-Emission Tomography
Radiopharmaceuticals
Solid-Phase Synthesis Techniques
Tissue Distribution
Titanium
Xenograft Model Antitumor Assays

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10.1021/acs.jmedchem.5b01167

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Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic). / Severin, Gregory; Nielsen, Carsten H; Jensen, Andreas I et al.
In: Journal of Medicinal Chemistry, Vol. 58, No. 18, 24.09.2015, p. 7591-5.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.",

keywords = "Animals, Antineoplastic Agents, Coordination Complexes, HT29 Cells, Humans, Mice, Nude, Positron-Emission Tomography, Radiopharmaceuticals, Solid-Phase Synthesis Techniques, Tissue Distribution, Titanium, Xenograft Model Antitumor Assays",

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doi = "10.1021/acs.jmedchem.5b01167",

language = "English",

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AU - Severin, Gregory

AU - Nielsen, Carsten H

AU - Jensen, Andreas I

AU - Fonslet, Jesper

AU - Kjær, Andreas

AU - Zhuravlev, Fedor

PY - 2015/9/24

Y1 - 2015/9/24

N2 - We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

AB - We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

KW - Animals

KW - Antineoplastic Agents

KW - Coordination Complexes

KW - HT29 Cells

KW - Humans

KW - Mice, Nude

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Solid-Phase Synthesis Techniques

KW - Tissue Distribution

KW - Titanium

KW - Xenograft Model Antitumor Assays

UR - https://www.scopus.com/pages/publications/84942333174

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DO - 10.1021/acs.jmedchem.5b01167

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JO - Journal of Medicinal Chemistry

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IS - 18

ER -

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic)

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Keywords

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