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Brief Assessment of Impaired Cognition (BASIC)-Validation of a new dementia case-finding instrument integrating cognitive assessment with patient and informant report

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@article{6d11b163fb544906a33d3784214059f1,
title = "Brief Assessment of Impaired Cognition (BASIC)-Validation of a new dementia case-finding instrument integrating cognitive assessment with patient and informant report",
abstract = "OBJECTIVES: The aim of this study was to develop and validate a new brief and accurate case-finding instrument for dementia and cognitive impairment. Previous research indicates that combining cognitive tests with informant and/or patient report may improve accuracy in dementia case-finding. The Brief Assessment of Impaired Cognition (BASIC) integrates these three sources of information.METHODS: BASIC was prospectively validated in five memory clinics. Patients consecutively referred from general practice were tested at their initial visit prior to diagnosis. Control participants were primarily recruited among participating patients' relatives. Expert clinical diagnosis was subsequently used as gold standard for estimation of the classification accuracy of BASIC.RESULTS: A very high discriminative validity (specificity 0.98, sensitivity 0.95) for dementia (n = 122) versus socio-demographically matched control participants (n = 109) was found. In comparison, the MMSE had 0.90 specificity and 0.82 sensitivity. Extending the discriminative validity analysis to cognitive impairment (both dementia and MCI, n = 162) only slightly reduced the discriminative validity of BASIC whereas the discriminative validity of the MMSE was substantially attenuated. Administration time for BASIC was approximately 5 minutes compared with 10 to 15 minutes for the MMSE.CONCLUSIONS: BASIC was found to be an efficient and valid case-finding instrument for dementia and cognitive impairment in a memory clinic setting.",
keywords = "BASIC, cognitive assessment, cognitive impairment, cognitive screening, dementia, diagnostic accuracy, discriminative validity, predictive validity",
author = "Kasper J{\o}rgensen and Nielsen, {T Rune} and Ann Nielsen and Waldorff, {Frans Boch} and Peter H{\o}gh and S{\o}ren Jakobsen and Hanne Gottrup and Karsten Vestergaard and Gunhild Waldemar",
note = "{\textcopyright} 2019 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.",
year = "2019",
month = nov,
doi = "10.1002/gps.5188",
language = "English",
volume = "34",
pages = "1724--1733",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John/Wiley & Sons Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Brief Assessment of Impaired Cognition (BASIC)-Validation of a new dementia case-finding instrument integrating cognitive assessment with patient and informant report

AU - Jørgensen, Kasper

AU - Nielsen, T Rune

AU - Nielsen, Ann

AU - Waldorff, Frans Boch

AU - Høgh, Peter

AU - Jakobsen, Søren

AU - Gottrup, Hanne

AU - Vestergaard, Karsten

AU - Waldemar, Gunhild

N1 - © 2019 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.

PY - 2019/11

Y1 - 2019/11

N2 - OBJECTIVES: The aim of this study was to develop and validate a new brief and accurate case-finding instrument for dementia and cognitive impairment. Previous research indicates that combining cognitive tests with informant and/or patient report may improve accuracy in dementia case-finding. The Brief Assessment of Impaired Cognition (BASIC) integrates these three sources of information.METHODS: BASIC was prospectively validated in five memory clinics. Patients consecutively referred from general practice were tested at their initial visit prior to diagnosis. Control participants were primarily recruited among participating patients' relatives. Expert clinical diagnosis was subsequently used as gold standard for estimation of the classification accuracy of BASIC.RESULTS: A very high discriminative validity (specificity 0.98, sensitivity 0.95) for dementia (n = 122) versus socio-demographically matched control participants (n = 109) was found. In comparison, the MMSE had 0.90 specificity and 0.82 sensitivity. Extending the discriminative validity analysis to cognitive impairment (both dementia and MCI, n = 162) only slightly reduced the discriminative validity of BASIC whereas the discriminative validity of the MMSE was substantially attenuated. Administration time for BASIC was approximately 5 minutes compared with 10 to 15 minutes for the MMSE.CONCLUSIONS: BASIC was found to be an efficient and valid case-finding instrument for dementia and cognitive impairment in a memory clinic setting.

AB - OBJECTIVES: The aim of this study was to develop and validate a new brief and accurate case-finding instrument for dementia and cognitive impairment. Previous research indicates that combining cognitive tests with informant and/or patient report may improve accuracy in dementia case-finding. The Brief Assessment of Impaired Cognition (BASIC) integrates these three sources of information.METHODS: BASIC was prospectively validated in five memory clinics. Patients consecutively referred from general practice were tested at their initial visit prior to diagnosis. Control participants were primarily recruited among participating patients' relatives. Expert clinical diagnosis was subsequently used as gold standard for estimation of the classification accuracy of BASIC.RESULTS: A very high discriminative validity (specificity 0.98, sensitivity 0.95) for dementia (n = 122) versus socio-demographically matched control participants (n = 109) was found. In comparison, the MMSE had 0.90 specificity and 0.82 sensitivity. Extending the discriminative validity analysis to cognitive impairment (both dementia and MCI, n = 162) only slightly reduced the discriminative validity of BASIC whereas the discriminative validity of the MMSE was substantially attenuated. Administration time for BASIC was approximately 5 minutes compared with 10 to 15 minutes for the MMSE.CONCLUSIONS: BASIC was found to be an efficient and valid case-finding instrument for dementia and cognitive impairment in a memory clinic setting.

KW - BASIC

KW - cognitive assessment

KW - cognitive impairment

KW - cognitive screening

KW - dementia

KW - diagnostic accuracy

KW - discriminative validity

KW - predictive validity

UR - http://www.scopus.com/inward/record.url?scp=85070795728&partnerID=8YFLogxK

U2 - 10.1002/gps.5188

DO - 10.1002/gps.5188

M3 - Journal article

C2 - 31389089

VL - 34

SP - 1724

EP - 1733

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 11

ER -

ID: 58034707