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The Capital Region of Denmark - a part of Copenhagen University Hospital

Breast cancer in systemic lupus

Research output: Contribution to journalJournal articleResearchpeer-review


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  • S Bernatsky
  • R Ramsey-Goldman
  • M Petri
  • M B Urowitz
  • D D Gladman
  • P F Fortin
  • E Ginzler
  • J Romero-Diaz
  • C Peschken
  • S Jacobsen
  • J G Hanly
  • C Gordon
  • O Nived
  • E H Yelin
  • D Isenberg
  • A Rahman
  • S-C Bae
  • L Joseph
  • T Witte
  • G Ruiz-Irastorza
  • C Aranow
  • D Kamen
  • G Sturfeldt
  • W D Foulkes
  • J E Hansen
  • Y St Pierre
  • P Chrétien Raymer
  • B Tessier-Cloutier
  • A E Clarke
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Objective There is a decreased breast cancer risk in systemic lupus erythematosus (SLE) versus the general population. We assessed a large sample of SLE patients, evaluating demographic and clinical characteristics and breast cancer risk. Methods We performed case-cohort analyses within a multi-center international SLE sample. We calculated the breast cancer hazard ratio (HR) in female SLE patients, relative to demographics, reproductive history, family history of breast cancer, and time-dependent measures of anti-dsDNA positivity, cumulative disease activity, and drugs, adjusted for SLE duration. Results There were 86 SLE breast cancers and 4498 female SLE cancer-free controls. Patients were followed on average for 7.6 years. Versus controls, SLE breast cancer cases tended to be white and older. Breast cancer cases were similar to controls regarding anti-dsDNA positivity, disease activity, and most drug exposures over time. In univariate and multivariate models, the principal factor associated with breast cancers was older age at cohort entry. Conclusions There was little evidence that breast cancer risk in this SLE sample was strongly driven by any of the clinical factors that we studied. Further search for factors that determine the lower risk of breast cancer in SLE may be warranted.

Original languageEnglish
Issue number3
Pages (from-to)311-315
Number of pages5
Publication statusPublished - Mar 2017

    Research areas

  • Adult, Age Factors, Breast Neoplasms, Cohort Studies, Female, Humans, International Cooperation, Lupus Erythematosus, Systemic, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Risk Factors, Journal Article, Multicenter Study

ID: 52381506