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Brain structure associations with phonemic and semantic fluency in typically-developing children

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@article{6b7f49ef346c422cb1016541706937f8,
title = "Brain structure associations with phonemic and semantic fluency in typically-developing children",
abstract = "Verbal fluency is the ability to retrieve lexical knowledge quickly and efficiently and develops during childhood and adolescence. Few studies have investigated associations between verbal fluency performance and brain structural variation in children. Here we examined associations of verbal fluency performance with structural measures of frontal and temporal language-related brain regions and their connections in 73 typically-developing children aged 7-13 years. Tract-based spatial statistics was used to extract fractional anisotropy (FA) from the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and the white matter underlying frontal and temporal language-related regions. FreeSurfer was used to extract cortical thickness and surface area. Better semantic and phonemic fluency performance was associated with higher right SLF/AF FA, and phonemic fluency was also modestly associated with lower left SLF/AF FA. Explorative voxelwise analyses for semantic fluency suggested associations with FA in other fiber tracts, including corpus callosum and right inferior fronto-occipital fasciculus. Overall, our results suggest that verbal fluency performance in children may rely on right hemisphere structures, possibly involving both language and executive function networks, and less on solely left hemisphere structures as often is observed in adults. Longitudinal studies are needed to clarify whether these associations are mediated by maturational processes, stable characteristics and/or experience.",
keywords = "Category fluency, Diffusion tensor imaging, Letter fluency, MRI, superior longitudinal fasciculus, Surface area",
author = "Gonzalez, {Marybel Robledo} and Baar{\'e}, {William F C} and Hagler, {Donald J} and Sarah Archibald and Martin Vestergaard and Madsen, {Kathrine Skak}",
note = "Copyright {\textcopyright} 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
month = aug,
doi = "10.1016/j.dcn.2021.100982",
language = "English",
volume = "50",
journal = "Developmental cognitive neuroscience",
issn = "1878-9293",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Brain structure associations with phonemic and semantic fluency in typically-developing children

AU - Gonzalez, Marybel Robledo

AU - Baaré, William F C

AU - Hagler, Donald J

AU - Archibald, Sarah

AU - Vestergaard, Martin

AU - Madsen, Kathrine Skak

N1 - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - Verbal fluency is the ability to retrieve lexical knowledge quickly and efficiently and develops during childhood and adolescence. Few studies have investigated associations between verbal fluency performance and brain structural variation in children. Here we examined associations of verbal fluency performance with structural measures of frontal and temporal language-related brain regions and their connections in 73 typically-developing children aged 7-13 years. Tract-based spatial statistics was used to extract fractional anisotropy (FA) from the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and the white matter underlying frontal and temporal language-related regions. FreeSurfer was used to extract cortical thickness and surface area. Better semantic and phonemic fluency performance was associated with higher right SLF/AF FA, and phonemic fluency was also modestly associated with lower left SLF/AF FA. Explorative voxelwise analyses for semantic fluency suggested associations with FA in other fiber tracts, including corpus callosum and right inferior fronto-occipital fasciculus. Overall, our results suggest that verbal fluency performance in children may rely on right hemisphere structures, possibly involving both language and executive function networks, and less on solely left hemisphere structures as often is observed in adults. Longitudinal studies are needed to clarify whether these associations are mediated by maturational processes, stable characteristics and/or experience.

AB - Verbal fluency is the ability to retrieve lexical knowledge quickly and efficiently and develops during childhood and adolescence. Few studies have investigated associations between verbal fluency performance and brain structural variation in children. Here we examined associations of verbal fluency performance with structural measures of frontal and temporal language-related brain regions and their connections in 73 typically-developing children aged 7-13 years. Tract-based spatial statistics was used to extract fractional anisotropy (FA) from the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and the white matter underlying frontal and temporal language-related regions. FreeSurfer was used to extract cortical thickness and surface area. Better semantic and phonemic fluency performance was associated with higher right SLF/AF FA, and phonemic fluency was also modestly associated with lower left SLF/AF FA. Explorative voxelwise analyses for semantic fluency suggested associations with FA in other fiber tracts, including corpus callosum and right inferior fronto-occipital fasciculus. Overall, our results suggest that verbal fluency performance in children may rely on right hemisphere structures, possibly involving both language and executive function networks, and less on solely left hemisphere structures as often is observed in adults. Longitudinal studies are needed to clarify whether these associations are mediated by maturational processes, stable characteristics and/or experience.

KW - Category fluency

KW - Diffusion tensor imaging

KW - Letter fluency

KW - MRI

KW - superior longitudinal fasciculus

KW - Surface area

UR - http://www.scopus.com/inward/record.url?scp=85108344742&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2021.100982

DO - 10.1016/j.dcn.2021.100982

M3 - Journal article

C2 - 34171560

VL - 50

JO - Developmental cognitive neuroscience

JF - Developmental cognitive neuroscience

SN - 1878-9293

M1 - 100982

ER -

ID: 66508321