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Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

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  3. Structural changes induced by electroconvulsive therapy are associated with clinical outcome

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  • Olga Therese Ousdal
  • Miklos Argyelan
  • Katherine L Narr
  • Christopher Abbott
  • Benjamin Wade
  • Mathieu Vandenbulcke
  • Mikel Urretavizcaya
  • Indira Tendolkar
  • Akihiro Takamiya
  • Max L Stek
  • Carles Soriano-Mas
  • Ronny Redlich
  • Olaf B Paulson
  • Mardien L Oudega
  • Nils Opel
  • Pia Nordanskog
  • Taishiro Kishimoto
  • Robin Kampe
  • Anders Jorgensen
  • J Paul Hamilton
  • Randall Espinoza
  • Louise Emsell
  • Philip van Eijndhoven
  • Annemieke Dols
  • Lars G Hanson
  • Udo Dannlowski
  • Narcis Cardoner
  • Filip Bouckaert
  • Amit Anand
  • Hauke Bartsch
  • Ute Kessler
  • Ketil J Oedegaard
  • Anders M Dale
  • Leif Oltedal
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BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response.

METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites.

RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation ρ = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome.

CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.

Original languageEnglish
JournalBiological Psychiatry
Volume87
Issue number5
Pages (from-to)451-461
Number of pages11
ISSN0006-3223
DOIs
Publication statusPublished - 1 Mar 2020

Bibliographical note

The following GEMRIC collaborators contributed to this work: Vera Jane
Erchinger, Jan Haavik, Ole Johan Evjenth Sørhaug, Martin B. Jørgensen,
Tom G. Bolwig, Peter Magnusson, Marta Cano, Jesús Pujol, José M.
Menchón, Georgios Petrides, and Pascal Sienaert. The full overview of the
GEMRIC board members can be found here: https://helse-bergen.no/en/
avdelinger/psykisk-helsevern/forskingsavdelinga-divisjon-psykisk-helsevern/
gemric-the-global-ect-mri-research-collaboration/gemric-the-global-ectmriresearch-collaboration.

    Research areas

  • Antidepressant, Biomarker, Brain, Depression, ECT, Magnetic resonance imaging, Neuroimaging

ID: 58033647