Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk; Anna Lind Hansen; Esben Thade Petersen; Hartwig R. Siebner; Anouk Marsman

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Carl-Johan Boraxbekk, Anna Lind Hansen, Esben Thade Petersen, Hartwig R. Siebner, Anouk Marsman

Abstract

Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

Original language	English
Title of host publication	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages	1
Publisher	The International Society for Magnetic Resonance in Medicine
Publication date	2020
Pages	1-1
Article number	1853
Publication status	Published - 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Duration: 8 Aug 2020 → 14 Aug 2020 https://www.ismrm.org/20m/

Conference

Conference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Location	Virtual conference
Period	08/08/2020 → 14/08/2020
Internet address	https://www.ismrm.org/20m/

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Boraxbekk, C-J., Hansen, A. L., Petersen, E. T., Siebner, H. R., & Marsman, A. (2020). Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. In Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 1-1). [1853] The International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2020/1853.html

Brain and immune system crosstalk : Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. / Boraxbekk, Carl-Johan; Hansen, Anna Lind; Petersen, Esben Thade et al.

Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. p. 1-1 1853.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

Boraxbekk, C-J, Hansen, AL, Petersen, ET , Siebner, HR & Marsman, A 2020, Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T. in Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 1853, The International Society for Magnetic Resonance in Medicine, pp. 1-1, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/1853.html>

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abstract = "Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.",

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AU - Siebner, Hartwig R.

AU - Marsman, Anouk

PY - 2020

Y1 - 2020

N2 - Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

AB - Inflammation is proposed as one of the central pillars driving ageing. This study was the first to link peripheral inflammation to brain metabolite differences during normal ageing and to associate this to visuo-spatial working memory performance. Our data shows how peripheral inflammatory markers were associated with performance on visuo-spatial working memory and glial metabolic markers in ACC, Hippocampus, and Thalamus. The findings highlight the role of glial cells as part of the neurobiological link between peripheral inflammation and cognitive performance during ageing.

M3 - Conference abstract in proceedings

SP - 1

EP - 1

BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

Y2 - 8 August 2020 through 14 August 2020

ER -

Brain and immune system crosstalk: Examining the link between proinflammatory markers and glial markers measured with 1H-MRS at 7T

Abstract

Conference

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