Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Bovine Colostrum For Preterm Infants in the First Days of Life: A Randomized Controlled Pilot Trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Serum Calprotectin in Adolescents with Inflammatory Bowel Disease - A Pilot Investigation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. F-calprotectin and blood markers correlate to Quality of Life in Pediatric Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Surgical Management of Crohn Disease in Children - Guidelines from the Paediatric IBD Porto Group of ESPGHAN

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effect of Probiotics on Diarrhea in Children With Severe Acute Malnutrition: A Randomized Controlled Study in Uganda

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: Mother's own milk (MM) is the best nutrition for newborn preterm infants, but is often limited in supply just after birth. Pasteurized human donor milk (DM), and especially preterm infant formula (IF) are less optimal diets than MM. We hypothesized that it is feasible to use bovine colostrum (BC), the first milk from cows, as a supplement to MM, during the first weeks after preterm birth.

METHODS: In an open-label, randomized, controlled pilot safety trial, supplementation of MM with BC was compared with DM supplementation (Danish unit) or IF supplementation (Chinese unit). If MM was limited or lacking, BC, DM or IF were given according to local feeding guidelines during the first 14 days of life.

RESULTS: Forty infants were included and randomized in Denmark and in China, with gestational ages 29.9 ± 0.4 and 31.1 ± 0.2 weeks, respectively. Infants supplemented with BC received more enteral protein (P < 0.05) and tended to reach full enteral feeding earlier (China only). Eight infants fed BC showed a temporary elevation in plasma tyrosine on d 7, versus two infants in the DM/IF groups. There were no differences between diet groups in feeding intolerance or clinical adverse events.

CONCLUSION: Our results indicate that it is feasible to use BC as a supplement to MM during the first weeks of life to increase enteral protein intake in preterm infants. Plasma tyrosine levels may be a good marker for excessive protein intake. A larger randomized trial is required to test the safety and possible short- and long-term clinical benefits of BC supplementation during the first weeks of life for preterm infants.

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume66
Issue number3
Pages (from-to)471-478
ISSN0277-2116
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52371909