Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations

Elsayed Z Soliman; Jens D Lundgren; Mollie P Roediger; Daniel A Duprez; Zelalem Temesgen; Markus Bickel; Judith C Shlay; Charurut Somboonwit; Peter Reiss; James H Stein; James D Neaton; INSIGHT SMART Study Group

doi:10.1097/QAD.0b013e328341dcc0

Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations

Elsayed Z Soliman, Jens D Lundgren, Mollie P Roediger, Daniel A Duprez, Zelalem Temesgen, Markus Bickel, Judith C Shlay, Charurut Somboonwit, Peter Reiss, James H Stein, James D Neaton, INSIGHT SMART Study Group

67 Citations (Scopus)

Abstract

There are contradictory reports regarding the effects of protease inhibitors on the ECG measures of QT and PR interval durations. The effect of interrupting use of protease inhibitors on QT and PR progression is also unknown.

Original language	English
Journal	AIDS
Volume	25
Issue number	3
Pages (from-to)	367-77
Number of pages	11
ISSN	0269-9370
DOIs	https://doi.org/10.1097/QAD.0b013e328341dcc0
Publication status	Published - 28 Jan 2011

Keywords

Adult
Anti-Retroviral Agents
Dose-Response Relationship, Drug
Electrocardiography, Ambulatory
Female
HIV-1
Humans
Long QT Syndrome
Male
Protease Inhibitors
Treatment Outcome
Viral Load

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10.1097/QAD.0b013e328341dcc0

Cite this

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title = "Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations",

abstract = "There are contradictory reports regarding the effects of protease inhibitors on the ECG measures of QT and PR interval durations. The effect of interrupting use of protease inhibitors on QT and PR progression is also unknown.",

keywords = "Adult, Anti-Retroviral Agents, Dose-Response Relationship, Drug, Electrocardiography, Ambulatory, Female, HIV-1, Humans, Long QT Syndrome, Male, Protease Inhibitors, Treatment Outcome, Viral Load",

author = "Soliman, \{Elsayed Z\} and Lundgren, \{Jens D\} and Roediger, \{Mollie P\} and Duprez, \{Daniel A\} and Zelalem Temesgen and Markus Bickel and Shlay, \{Judith C\} and Charurut Somboonwit and Peter Reiss and Stein, \{James H\} and Neaton, \{James D\} and \{INSIGHT SMART Study Group\}",

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T1 - Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations

AU - Soliman, Elsayed Z

AU - Lundgren, Jens D

AU - Roediger, Mollie P

AU - Duprez, Daniel A

AU - Temesgen, Zelalem

AU - Bickel, Markus

AU - Shlay, Judith C

AU - Somboonwit, Charurut

AU - Reiss, Peter

AU - Stein, James H

AU - Neaton, James D

AU - INSIGHT SMART Study Group

PY - 2011/1/28

Y1 - 2011/1/28

N2 - There are contradictory reports regarding the effects of protease inhibitors on the ECG measures of QT and PR interval durations. The effect of interrupting use of protease inhibitors on QT and PR progression is also unknown.

AB - There are contradictory reports regarding the effects of protease inhibitors on the ECG measures of QT and PR interval durations. The effect of interrupting use of protease inhibitors on QT and PR progression is also unknown.

KW - Adult

KW - Anti-Retroviral Agents

KW - Dose-Response Relationship, Drug

KW - Electrocardiography, Ambulatory

KW - Female

KW - HIV-1

KW - Humans

KW - Long QT Syndrome

KW - Male

KW - Protease Inhibitors

KW - Treatment Outcome

KW - Viral Load

UR - https://www.scopus.com/pages/publications/79551597268

U2 - 10.1097/QAD.0b013e328341dcc0

DO - 10.1097/QAD.0b013e328341dcc0

M3 - Journal article

C2 - 21150558

SN - 0269-9370

VL - 25

SP - 367

EP - 377

JO - AIDS

JF - AIDS

IS - 3

ER -

Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations

Abstract

Keywords

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