Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Bone turnover markers in children and adolescents with type 1 diabetes-A systematic review

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Low carbohydrate diet elevates blood sphingomyelin in people with type 1 diabetes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  3. N-glycosylation of plasma proteins is changed in children with early onset type 1 diabetes and regulated by glycosyltransferase and complement C3 genes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations

Type 1 diabetes (T1D) is associated with impaired bone health and both osteocalcin (OCN) and procollagen type 1 amino terminal propetide (P1NP) (markers of bone formation) and C-terminal cross-linked telopeptide (CTX) (marker of bone resorption) are decreased in adult patients with T1D. We review the existing literature characterizing these bone turnover markers in children and adolescents with T1D and by meta-analysis examine whether alterations in OCN, P1NP, and CTX are evident and if potential changes correlate to the metabolic control (hemoglobin A1c, HbA1c). Systematic searches at MEDLINE and EMBASE were conducted in January 2018 identifying all studies describing OCN, P1NP, or CTX in children and adolescents with T1D. A total of 26 studies were included, representing data from more than 1000 patients with T1D. Pooled analyses of standard mean difference and summary effects analysis were performed when sufficient data were available. Pooled analysis revealed mean OCN to be significantly lower in children and adolescents with T1D compared to healthy controls (standard mean difference: -1.87, 95% confidence interval, CI: -2.83; -0.91) whereas both P1NP and CTX did not differ from the controls. Only data on OCN was sufficient to make pooled correlation analysis revealing a negative correlation between OCN and HbA1c (-0.31 95% CI: -0.45; -0.16). In conclusion, OCN is decreased in children and adolescents with T1D, whether CTX and P1NP are affected as well is unclear, due to very limited data available. New and large studies including OCN, P1NP, and CTX (preferably as z-scores adjusting for age variability) is needed to further elucidate the status of bone turnover in children and adolescents with T1D.

Original languageEnglish
JournalPediatric Diabetes
Volume20
Issue number5
Pages (from-to)510-522
Number of pages13
ISSN1399-543X
DOIs
Publication statusPublished - 1 Aug 2019

    Research areas

  • adolescent, bone remodeling, child, osteocalcin, type 1 diabetes

ID: 57291771