Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Screening for retinopathy in children with type 1 diabetes in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bone turnover markers in children and adolescents with type 1 diabetes - A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  1. Effect of dosage of 17ß-estradiol on uterine growth in Turner syndrome - a randomized controlled clinical pilot trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bone resorption is unchanged by liraglutide in type 2 diabetes patients: A randomised controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background and aim: In rodents, osteocalcin (OCN) stimulates insulin production and insulin sensitivity, both important factors during partial remission in humans with type 1 diabetes (T1D). However, decreased OCN has been reported in both adult and pediatric T1D. This study aims at investigating bone turnover and partial remission in children and adolescents with recent onset T1D. Subjects and methods: Ninety-nine individuals (33% girls) were recruited within 3 months of T1D onset and examined three times, 6 months apart. Outcome variables were bone formation markers OCN and procollagen type 1 amino-terminal propeptide (P1NP) and the bone resorption marker C-terminal crosslinked telopeptide of type 1 collagen (CTX). Dependent variables included IDAA1c (surrogate marker of partial remission), total body bone mineral density (BMD) and stimulated C-peptide as representative of endogenous insulin production. Results: OCN- and P1NP Z-scores were significantly decreased throughout the study, whereas CTX Z-scores were increased. None of the bone turnover markers changed significantly between visits. Total body BMD Z-score did not change during the study but was significantly higher than the reference population at visit 2 (P =.035). There were no differences in the bone turnover markers for those in partial remission as defined by either C-peptide or IDAA1c at any visit. The individual change in CTX Z-score was negatively associated with the increase of IDAA1c (P =.030) independent of C-peptide decline (P =.034). Conclusion: Bone turnover markers indicate increased bone resorption and decreased bone formation during the first year of T1D. The negative association between bone resorption and IDAA1c might represent compensatory mechanisms affecting insulin sensitivity.

Original languageEnglish
JournalPediatric Diabetes
Volume21
Issue number2
Pages (from-to)366-376
Number of pages11
ISSN1399-543X
DOIs
Publication statusPublished - Mar 2020

Bibliographical note

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

    Research areas

  • bone density, bone remodeling, C-peptide, diabetes mellitus, type 1, osteocalcin

ID: 58635893