Bone mineral status in children with cow milk allergy

Vagn Braendholt Jensen, Inger Merete Jørgensen, Kirsten Braendholt Rasmussen, Christian Mølgaard, Palle Prahl


To investigate bone mineral status in children with verified cow milk allergy for more than 4 yr compared with a large reference population of 343 local healthy controls. Whole body bone mineral content (BMC), projected bone area and bone mineral density (BMD) were determined by dual energy x-ray absorptiometry in nine children (8-17 yr old, one girl and eight boys). All children had cow milk allergy for more than 4 yr. All children had asthma and was treated with corticosteroids. BMC and BMD were reduced for age (p < 0.01). Height for age was significantly reduced (p < 0.01), indicating 'short' bones. BMC for bone area was borderline reduced (p = 0.05), indicating reduced bone mineralization. The growth of the children was reduced compared with there parents and siblings (p < 0.01), and the bone age was retarded (mean 1.4 yr, p < 0.01). Calcium consumption calculated from food intake was about 25% of the recommended. All laboratory tests were normal. Short bones were the main reason for reduced BMC and BMD for age in children with cow milk allergy, but a borderline low BMC for bone area indicated reduced bone mineralization of the bones. A supplementation of calcium to children with cow milk allergy is recommended.

Original languageEnglish
JournalPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Issue number6
Pages (from-to)562-5
Number of pages4
Publication statusPublished - Dec 2004


  • Absorptiometry, Photon/methods
  • Adolescent
  • Adrenal Cortex Hormones/therapeutic use
  • Asthma/complications
  • Body Height/physiology
  • Body Weight/physiology
  • Bone Density/physiology
  • Bone Development/physiology
  • Calcium, Dietary/blood
  • Child
  • Feeding Behavior/physiology
  • Female
  • Humans
  • Male
  • Milk Hypersensitivity/blood
  • Reference Values
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Time Factors


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