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Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age

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Wibaek, Rasmus ; Vistisen, Dorte ; Girma, Tsinuel ; Admassu, Bitiya ; Abera, Mubarek ; Abdissa, Alemseged ; Mudie, Kissi ; Kæstel, Pernille ; Jørgensen, Marit E ; Wells, Jonathan C K ; Michaelsen, Kim F ; Friis, Henrik ; Andersen, Gregers S. / Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age. In: The American journal of clinical nutrition. 2019 ; Vol. 110, No. 5. pp. 1175–1185.

Bibtex

@article{5091aa6c20ab454daa2b7011d95975d3,
title = "Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age",
abstract = "BACKGROUND: Both impaired and accelerated postnatal growth have been associated with adult risks of obesity and cardiometabolic diseases, like type 2 diabetes and cardiovascular disease. However, the timing of the onset of cardiometabolic changes and the specific growth trajectories linking early growth with later disease risks are not well understood.OBJECTIVES: The aim of this study was to identify distinct trajectories of BMI growth from 0 to 5 y and examine their associations with body composition and markers of cardiometabolic risk at age 5 y.METHODS: In a prospective birth cohort study of 453 healthy and term Ethiopian children with BMIs assessed a median of 9 times during follow-up, we identified subgroups of distinct BMI trajectories in early childhood using latent class trajectory modeling. Associations of the identified growth trajectories with cardiometabolic markers and body composition at 5 y were analyzed using multiple linear regression analyses in 4 adjustment models for each outcome.RESULTS: We identified 4 heterogeneous BMI growth trajectories: stable low BMI (19.2%), normal BMI (48.8%), rapid catch-up to high BMI (17.9%), and slow catch-up to high BMI (14.1%). Compared with the normal BMI trajectory, children in the rapid catch-up to high BMI trajectory had higher triglycerides (TGs) (range of β-coefficients in Models 1-4: 19-21%), C-peptides (23-25%), fat masses (0.48-0.60 kg), and fat-free masses (0.50-0.77 kg) across the 4 adjustment models. Children in the stable low BMI trajectory had lower LDL cholesterol concentrations (0.14-0.17 mmol/L), HDL cholesterol concentrations (0.05-0.09 mmol/L), fat masses (0.60-0.64 kg), and fat-free masses (0.35-0.49 kg), but higher TGs (11-13%).CONCLUSIONS: The development of obesity and cardiometabolic risks may be established already in early childhood; thus, our data provide a further basis for timely interventions targeted at young children from low-income countries with unfavorable growth patterns. The birth cohort was registered at ISRCTN as ISRCTN46718296.",
keywords = "body composition, child, cohort study, developmental origins of health and disease, growth, latent class trajectory modeling, noncommunicable diseases, sub-Saharan Africa",
author = "Rasmus Wibaek and Dorte Vistisen and Tsinuel Girma and Bitiya Admassu and Mubarek Abera and Alemseged Abdissa and Kissi Mudie and Pernille K{\ae}stel and J{\o}rgensen, {Marit E} and Wells, {Jonathan C K} and Michaelsen, {Kim F} and Henrik Friis and Andersen, {Gregers S}",
note = "Copyright {\textcopyright} American Society for Nutrition 2019.",
year = "2019",
month = nov,
day = "1",
doi = "10.1093/ajcn/nqz170",
language = "English",
volume = "110",
pages = "1175–1185",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

RIS

TY - JOUR

T1 - Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age

AU - Wibaek, Rasmus

AU - Vistisen, Dorte

AU - Girma, Tsinuel

AU - Admassu, Bitiya

AU - Abera, Mubarek

AU - Abdissa, Alemseged

AU - Mudie, Kissi

AU - Kæstel, Pernille

AU - Jørgensen, Marit E

AU - Wells, Jonathan C K

AU - Michaelsen, Kim F

AU - Friis, Henrik

AU - Andersen, Gregers S

N1 - Copyright © American Society for Nutrition 2019.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND: Both impaired and accelerated postnatal growth have been associated with adult risks of obesity and cardiometabolic diseases, like type 2 diabetes and cardiovascular disease. However, the timing of the onset of cardiometabolic changes and the specific growth trajectories linking early growth with later disease risks are not well understood.OBJECTIVES: The aim of this study was to identify distinct trajectories of BMI growth from 0 to 5 y and examine their associations with body composition and markers of cardiometabolic risk at age 5 y.METHODS: In a prospective birth cohort study of 453 healthy and term Ethiopian children with BMIs assessed a median of 9 times during follow-up, we identified subgroups of distinct BMI trajectories in early childhood using latent class trajectory modeling. Associations of the identified growth trajectories with cardiometabolic markers and body composition at 5 y were analyzed using multiple linear regression analyses in 4 adjustment models for each outcome.RESULTS: We identified 4 heterogeneous BMI growth trajectories: stable low BMI (19.2%), normal BMI (48.8%), rapid catch-up to high BMI (17.9%), and slow catch-up to high BMI (14.1%). Compared with the normal BMI trajectory, children in the rapid catch-up to high BMI trajectory had higher triglycerides (TGs) (range of β-coefficients in Models 1-4: 19-21%), C-peptides (23-25%), fat masses (0.48-0.60 kg), and fat-free masses (0.50-0.77 kg) across the 4 adjustment models. Children in the stable low BMI trajectory had lower LDL cholesterol concentrations (0.14-0.17 mmol/L), HDL cholesterol concentrations (0.05-0.09 mmol/L), fat masses (0.60-0.64 kg), and fat-free masses (0.35-0.49 kg), but higher TGs (11-13%).CONCLUSIONS: The development of obesity and cardiometabolic risks may be established already in early childhood; thus, our data provide a further basis for timely interventions targeted at young children from low-income countries with unfavorable growth patterns. The birth cohort was registered at ISRCTN as ISRCTN46718296.

AB - BACKGROUND: Both impaired and accelerated postnatal growth have been associated with adult risks of obesity and cardiometabolic diseases, like type 2 diabetes and cardiovascular disease. However, the timing of the onset of cardiometabolic changes and the specific growth trajectories linking early growth with later disease risks are not well understood.OBJECTIVES: The aim of this study was to identify distinct trajectories of BMI growth from 0 to 5 y and examine their associations with body composition and markers of cardiometabolic risk at age 5 y.METHODS: In a prospective birth cohort study of 453 healthy and term Ethiopian children with BMIs assessed a median of 9 times during follow-up, we identified subgroups of distinct BMI trajectories in early childhood using latent class trajectory modeling. Associations of the identified growth trajectories with cardiometabolic markers and body composition at 5 y were analyzed using multiple linear regression analyses in 4 adjustment models for each outcome.RESULTS: We identified 4 heterogeneous BMI growth trajectories: stable low BMI (19.2%), normal BMI (48.8%), rapid catch-up to high BMI (17.9%), and slow catch-up to high BMI (14.1%). Compared with the normal BMI trajectory, children in the rapid catch-up to high BMI trajectory had higher triglycerides (TGs) (range of β-coefficients in Models 1-4: 19-21%), C-peptides (23-25%), fat masses (0.48-0.60 kg), and fat-free masses (0.50-0.77 kg) across the 4 adjustment models. Children in the stable low BMI trajectory had lower LDL cholesterol concentrations (0.14-0.17 mmol/L), HDL cholesterol concentrations (0.05-0.09 mmol/L), fat masses (0.60-0.64 kg), and fat-free masses (0.35-0.49 kg), but higher TGs (11-13%).CONCLUSIONS: The development of obesity and cardiometabolic risks may be established already in early childhood; thus, our data provide a further basis for timely interventions targeted at young children from low-income countries with unfavorable growth patterns. The birth cohort was registered at ISRCTN as ISRCTN46718296.

KW - body composition

KW - child

KW - cohort study

KW - developmental origins of health and disease

KW - growth

KW - latent class trajectory modeling

KW - noncommunicable diseases

KW - sub-Saharan Africa

UR - http://www.scopus.com/inward/record.url?scp=85074308617&partnerID=8YFLogxK

U2 - 10.1093/ajcn/nqz170

DO - 10.1093/ajcn/nqz170

M3 - Journal article

C2 - 31504088

VL - 110

SP - 1175

EP - 1185

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -

ID: 57974960