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Blunted cardiovascular effects of beta-blockers in patients with cirrhosis: Relation to severity?

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  1. Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis

    Research output: Contribution to journalJournal articlepeer-review

  2. Cardiovascular mapping in cirrhosis from the compensated stage to hepatorenal syndrome: A Magnetic Resonance Study

    Research output: Contribution to journalJournal articlepeer-review

  3. Cirrhotic cardiomyopathy: Toward an optimized definition

    Research output: Contribution to journalEditorialpeer-review

  4. Editorial: timing of carvedilol - promoting survivors in cirrhosis

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AIMS: Patients with cirrhosis and portal hypertension are at high risk of developing complications such as variceal hemorrhage, ascites, and cardiac dysfunction, the latter of which is known as cirrhotic cardiomyopathy. Since non-selective beta-blockers (NSBB) may aggravate hemodynamic complications we investigated the effect of real-time propranolol infusion on cardiac function in patients with varying degrees of cirrhosis.

METHODS: Thirty-eight patients with Child-Pugh A (n = 17), B (n = 17) and C (n = 4) underwent liver vein catheterization and cardiac magnetic resonance imaging. We assessed the effect of real-time propranolol infusion on the hepatic venous pressure gradient, cardiac index, stroke volume, ejection fraction, heart rate, and contractility.

RESULTS: Nineteen patients were classified as responders to beta-blocker therapy. In pooling Child-Pugh B and C patients, the reduction in cardiac index by beta-blockade was weaker than in Child-Pugh A patients (-8.5% vs. -20.5%, p = 0.043). The effect of NSBB on portal pressure was inversely correlated to changes in the left atrium where the left atrial volume changed by 4 mL±18 in responders compared to 15 mL±11 in non-responders (p = 0.03). Finally, the baseline ejection fraction correlated inversely with the reduction in portal pressure (r = -0.39, p = 0.02).

CONCLUSION: We found the effect of beta-blockade on cardiac index in patients with advanced cirrhosis to be less potent than in patients with early cirrhosis, indicating that underlying cirrhotic cardiomyopathy increases, and the cardiac compensatory reserve becomes more compromised, with disease progression. The differential effects of beta-blockade in the left atrium may be used to predict the effect of beta-blockers on portal pressure, but further studies are needed to investigate this possibility.

Original languageEnglish
Article numbere0270603
JournalPLoS One
Volume17
Issue number6
Pages (from-to)1-16
Number of pages16
ISSN1932-6203
DOIs
Publication statusPublished - 28 Jun 2022

    Research areas

  • Adrenergic beta-Antagonists/pharmacology, Esophageal and Gastric Varices/complications, Gastrointestinal Hemorrhage/complications, Humans, Liver Cirrhosis/complications, Propranolol/pharmacology

ID: 79112269