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Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study

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Harvard

Larsen, SD, Dalgård, C, Christensen, ME, Lykkedegn, S, Andersen, LB, Andersen, M, Glintborg, D & Christesen, HT 2018, 'Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study', Endocrine Connections, vol. 7, no. 12, pp. 1236-1244. https://doi.org/10.1530/EC-18-0308

APA

Larsen, S. D., Dalgård, C., Christensen, M. E., Lykkedegn, S., Andersen, L. B., Andersen, M., Glintborg, D., & Christesen, H. T. (2018). Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study. Endocrine Connections, 7(12), 1236-1244. https://doi.org/10.1530/EC-18-0308

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MLA

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Author

Larsen, Søs Dragsbæk ; Dalgård, Christine ; Christensen, Mathilde Egelund ; Lykkedegn, Sine ; Andersen, Louise Bjørkholt ; Andersen, Marianne ; Glintborg, Dorte ; Christesen, Henrik Thybo. / Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D : an Odense Child Cohort study. In: Endocrine Connections. 2018 ; Vol. 7, No. 12. pp. 1236-1244.

Bibtex

@article{6f63022c100d45928ae318d5101cb9d3,
title = "Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study",
abstract = "Background Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design Prospective, population-based cohort study. Methods We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results In 3-year-old girls, SBP decreased with -0.7 mmHg (95% CI -1.1; -0.3, P = 0.001) and DBP with -0.4 mmHg (95% CI -0.7; -0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.",
author = "Larsen, {S{\o}s Dragsb{\ae}k} and Christine Dalg{\aa}rd and Christensen, {Mathilde Egelund} and Sine Lykkedegn and Andersen, {Louise Bj{\o}rkholt} and Marianne Andersen and Dorte Glintborg and Christesen, {Henrik Thybo}",
year = "2018",
month = dec,
day = "1",
doi = "10.1530/EC-18-0308",
language = "English",
volume = "7",
pages = "1236--1244",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D

T2 - an Odense Child Cohort study

AU - Larsen, Søs Dragsbæk

AU - Dalgård, Christine

AU - Christensen, Mathilde Egelund

AU - Lykkedegn, Sine

AU - Andersen, Louise Bjørkholt

AU - Andersen, Marianne

AU - Glintborg, Dorte

AU - Christesen, Henrik Thybo

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design Prospective, population-based cohort study. Methods We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results In 3-year-old girls, SBP decreased with -0.7 mmHg (95% CI -1.1; -0.3, P = 0.001) and DBP with -0.4 mmHg (95% CI -0.7; -0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

AB - Background Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design Prospective, population-based cohort study. Methods We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results In 3-year-old girls, SBP decreased with -0.7 mmHg (95% CI -1.1; -0.3, P = 0.001) and DBP with -0.4 mmHg (95% CI -0.7; -0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

U2 - 10.1530/EC-18-0308

DO - 10.1530/EC-18-0308

M3 - Journal article

C2 - 30533001

VL - 7

SP - 1236

EP - 1244

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 12

ER -

ID: 56560597