Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis

Henrik Lund; Martin Krakauer; Arnold Skimminge; Finn Sellebjerg; Ellen Garde; Hartwig R Siebner; Olaf B Paulson; Dan Hesse; Lars G Hanson

doi:10.1371/journal.pone.0056375

Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis

Henrik Lund, Martin Krakauer, Arnold Skimminge, Finn Sellebjerg, Ellen Garde, Hartwig R Siebner, Olaf B Paulson, Dan Hesse, Lars G Hanson

54 Citations (Scopus)

Abstract

Multiple sclerosis (MS) affects the integrity of the blood-brain barrier (BBB). Contrast-enhanced T1 weighted magnetic resonance imaging (MRI) is widely used to characterize location and extent of BBB disruptions in focal MS lesions. We employed quantitative T1 measurements before and after the intravenous injection of a paramagnetic contrast agent to assess BBB permeability in the normal appearing white matter (NAWM) in patients with relapsing-remitting MS (RR-MS).

Original language	English
Journal	P L o S One
Volume	8
Issue number	2
Pages (from-to)	e56375
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0056375
Publication status	Published - 2013

Keywords

Adult
Blood-Brain Barrier
Brain
Case-Control Studies
Female
Gadolinium DTPA
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Permeability

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10.1371/journal.pone.0056375

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title = "Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis",

abstract = "Multiple sclerosis (MS) affects the integrity of the blood-brain barrier (BBB). Contrast-enhanced T1 weighted magnetic resonance imaging (MRI) is widely used to characterize location and extent of BBB disruptions in focal MS lesions. We employed quantitative T1 measurements before and after the intravenous injection of a paramagnetic contrast agent to assess BBB permeability in the normal appearing white matter (NAWM) in patients with relapsing-remitting MS (RR-MS).",

keywords = "Adult, Blood-Brain Barrier, Brain, Case-Control Studies, Female, Gadolinium DTPA, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Permeability",

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T1 - Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis

AU - Lund, Henrik

AU - Krakauer, Martin

AU - Skimminge, Arnold

AU - Sellebjerg, Finn

AU - Garde, Ellen

AU - Siebner, Hartwig R

AU - Paulson, Olaf B

AU - Hesse, Dan

AU - Hanson, Lars G

PY - 2013

Y1 - 2013

N2 - Multiple sclerosis (MS) affects the integrity of the blood-brain barrier (BBB). Contrast-enhanced T1 weighted magnetic resonance imaging (MRI) is widely used to characterize location and extent of BBB disruptions in focal MS lesions. We employed quantitative T1 measurements before and after the intravenous injection of a paramagnetic contrast agent to assess BBB permeability in the normal appearing white matter (NAWM) in patients with relapsing-remitting MS (RR-MS).

AB - Multiple sclerosis (MS) affects the integrity of the blood-brain barrier (BBB). Contrast-enhanced T1 weighted magnetic resonance imaging (MRI) is widely used to characterize location and extent of BBB disruptions in focal MS lesions. We employed quantitative T1 measurements before and after the intravenous injection of a paramagnetic contrast agent to assess BBB permeability in the normal appearing white matter (NAWM) in patients with relapsing-remitting MS (RR-MS).

KW - Adult

KW - Blood-Brain Barrier

KW - Brain

KW - Case-Control Studies

KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Permeability

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DO - 10.1371/journal.pone.0056375

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VL - 8

SP - e56375

JO - P L o S One

JF - P L o S One

IS - 2

ER -

Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis

Abstract

Keywords

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