There is today an expressed need for approved biomarkers that both can aid the diagnosis of Alzheimer's and Parkinson's diseases and guide the development of new treatments for these diseases. There are today two tests approved in Europe to aid the diagnosis of Alzheimer's disease at the dementia stage and both are based on the expression of several genes in blood that together generates a model that can predict the disease. At the same time no biomarker based on proteins or metabolites in blood has yet been approved. This chapter will review the current state of development of novel biomarkers for Alzheimer's and Parkinson's diseases based on the expression of genes in blood. The chapter will also try to explain why using gene expression likely will be a viable approach for the development of novel blood based biomarkers for neurodegenerative diseases.
|Title of host publication||Recent Trends in Gene Expression|
|Number of pages||18|
|Publisher||Nova Science Publishers, Inc|
|Publication date||1 Dec 2013|
|Publication status||Published - 1 Dec 2013|