Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Common mental disorders among young refugees in Sweden: The role of education and duration of residency

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypomania/Mania by DSM-5 definition based on daily smartphone-based patient-reported assessments

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Restriction of non-opioid analgesics sold over-the-counter in Denmark: A national study of impact on poisonings

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Psychotic experiences from preadolescence to adolescence: when should we be worried about adolescent risk behaviors?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Dr. Uhre et al. Reply

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations
Background: Concerns have been raised that synthetic oxytocin, a widely used obstetric tool for labor induction and augmentation, may have deleterious effects on the neuropsychological development of children. Few studies have examined the relationship between oxytocin-stimulated labor and emotional disorders.

Methods: We conducted a nationwide register-based cohort study including 677,629 singletons born in Denmark in the years 2000 to 2012 and followed through 2016 (median age = 10.6 years). Data on oxytocin-stimulation were obtained from the Danish Medical Birth Register. Cases of emotional disorders - anxiety, obsessive-compulsive disorder, mood or traumatic stress disorders or a redeemed prescription for a selective serotonin reuptake inhibitor - were identified using Danish patient and prescription registries.

Results: Oxytocin was used to stimulate 31% of births, and oxytocin-stimulated labor was not associated with childhood emotional disorders (HR = 1.05, 95% CI 0.99, 1.11) after adjustment for maternal history of psychopathology, antidepressants during pregnancy, cohabitation status, highest educational attainment, smoking status during pregnancy, birth year, and indications for labor stimulation. The crude cox model was also small and close to unity (HR = 1.09, 95% CI 1.03, 1.15).

Limitations: About 50% of our population had reached the age of 10 years, but the outcome included disorders with later average debut ages. Oxytocin dosage levels are not recorded in the registers.

Conclusions: Our small effect size estimates suggest that perinatal synthetic oxytocin does not contribute to the development of emotional disorders. Current evidence does not warrant revision of guidelines for the use of oxytocin in obstetrics.
Original languageEnglish
JournalJournal of Affective Disorders
Volume274
Pages (from-to)112-117
Number of pages6
ISSN0165-0327
Publication statusPublished - 1 Sep 2020

ID: 59938577